PMID- 16987885
OWN - NLM
STAT- MEDLINE
DCOM- 20061120
LR  - 20210108
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 15 Spec No 2
DP  - 2006 Oct 15
TI  - Type-2 diabetes: a cocktail of genetic discovery.
PG  - R202-9
AB  - Diabetes is one of the most challenging health problems of the 21st century with 
      an alarming increase in the prevalence of type-2 diabetes mellitus (T2DM) and 
      associated conditions such as hypertension, dyslipidemias and obesity. T2DM is a 
      complex genetic disease comprised of many metabolic disorders with a common 
      phenotype of glucose intolerance. Patients with T2DM would have inherited a 
      variety of different genetic factors that together with environmental factors 
      combine as the primary cause. This complicates the genetic study of the disease 
      and means that different methodological approaches are needed if we hope to 
      identify susceptibility genes and genetic variants. The biochemical and 
      physiological processes that underpin T2DM are still unclear although most 
      certainly involve impairment in insulin secretion and insulin action. In this 
      review, we will discuss the most exciting advances in understanding the genetics 
      of T2DM by looking at recent discoveries employing human association studies and 
      candidate genes arising from animal models.
FAU - Freeman, H
AU  - Freeman H
AD  - Medical Research Council, Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, 
      UK.
FAU - Cox, R D
AU  - Cox RD
LA  - eng
GR  - MC_U142661184/MRC_/Medical Research Council/United Kingdom
GR  - MC_UP_1502/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/etiology/*genetics/metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Genetics, Population
MH  - Humans
MH  - Insulin Resistance/genetics
MH  - Male
MH  - Mice
MH  - Models, Biological
MH  - Models, Genetic
MH  - Obesity/genetics
MH  - Risk Factors
RF  - 90
EDAT- 2006/09/22 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/09/22 09:00
PHST- 2006/09/22 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/09/22 09:00 [entrez]
AID - 15/suppl_2/R202 [pii]
AID - 10.1093/hmg/ddl191 [doi]
PST - ppublish
SO  - Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R202-9. doi: 10.1093/hmg/ddl191.