PMID- 16988039
OWN - NLM
STAT- MEDLINE
DCOM- 20061013
LR  - 20200225
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 26
IP  - 38
DP  - 2006 Sep 20
TI  - Modulation of transient and sustained response components of V4 neurons by 
      temporal crowding in flashed stimulus sequences.
PG  - 9683-94
AB  - The responses of extrastriate area V4 neurons to flashed visual stimuli were 
      examined to determine whether the responses to stimulus sequences occurring at 
      normal saccade and fixation timing intervals were degraded relative to longer 
      timing intervals. Stimuli were flashed in receptive fields in the near periphery 
      while monkeys maintained steady fixation. Short interstimulus intervals (ISIs) 
      resulted in an overall habituation style response reduction. The transient 
      component of responses to preferred stimuli was suppressed, often completely, 
      when the ISI was reduced below 100 ms into the range of saccadic durations. The 
      sustained response component weakened but remained intact. At short ISIs the 
      trailing activity from the preceding stimulus blended with onset activity from 
      the next stimulus, making it difficult to detect individual stimulus onset events 
      within the spike train. Habituation or conditioning effects were correlated with 
      the stimulus tuning sensitivity of the neuron but only loosely associated with 
      the actual level of V4 activation elicited by preceding stimuli. The results 
      suggest that sharply tuned neurons, because of their probabilistic inactivity, 
      are particularly sensitive to temporal change, whereas the sustained components 
      of broadly tuned neurons could provide a continuity of information flow across 
      visual transients, such as saccades, that do not alter significantly the view by 
      the neuron of the scene.
FAU - Motter, Brad C
AU  - Motter BC
AD  - Veterans Affairs Medical Center, Syracuse, New York 13210, USA. motterb@cnyrc.org
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
CIN - J Neurosci. 2007 Jan 24;27(4):723-4. PMID: 17256187
MH  - Action Potentials/physiology
MH  - Animals
MH  - Macaca mulatta
MH  - Neurons/*physiology
MH  - Photic Stimulation/*methods
MH  - Reaction Time/*physiology
MH  - Time Factors
MH  - Visual Cortex/*physiology
PMC - PMC6674438
EDAT- 2006/09/22 09:00
MHDA- 2006/10/14 09:00
PMCR- 2007/03/20
CRDT- 2006/09/22 09:00
PHST- 2006/09/22 09:00 [pubmed]
PHST- 2006/10/14 09:00 [medline]
PHST- 2006/09/22 09:00 [entrez]
PHST- 2007/03/20 00:00 [pmc-release]
AID - 26/38/9683 [pii]
AID - 3148210 [pii]
AID - 10.1523/JNEUROSCI.5495-05.2006 [doi]
PST - ppublish
SO  - J Neurosci. 2006 Sep 20;26(38):9683-94. doi: 10.1523/JNEUROSCI.5495-05.2006.