PMID- 16988041
OWN - NLM
STAT- MEDLINE
DCOM- 20061013
LR  - 20200225
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 26
IP  - 38
DP  - 2006 Sep 20
TI  - Tumor necrosis factor receptor 1 is a negative regulator of progenitor 
      proliferation in adult hippocampal neurogenesis.
PG  - 9703-12
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, acting 
      through the TNF-R1 and TNF-R2 receptors. The two receptors have been proposed to 
      mediate distinct TNF-alpha effects in the CNS, TNF-R1 contributing to neuronal 
      damage and TNF-R2 being neuroprotective. Whether TNF-alpha and its receptors play 
      any role for neurogenesis in the adult brain is unclear. Here we used mouse 
      models with loss of TNF-R1 and TNF-R2 function to establish whether signaling 
      through these receptors could influence hippocampal neurogenesis in vivo under 
      basal conditions, as well as after status epilepticus (SE), which is associated 
      with inflammation and elevated TNF-alpha levels. Notably, in the intact brain, 
      the number of new, mature hippocampal neurons was elevated in TNF-R1(-/-) and 
      TNF-R1/R2(-/-) mice, whereas no significant changes were detected in TNF-R2(-/-) 
      mice. Also after SE, the TNF-R1(-/-) and TNF-R1/R2(-/-) mice produced more new 
      neurons. In contrast, the TNF-R2(-/-) mice showed reduced SE-induced 
      neurogenesis. Cell proliferation in the dentate subgranular zone was elevated in 
      TNF-R1(-/-) and TNF-R1/R2(-/-) mice both under basal conditions and after SE. The 
      TNF-R2(-/-) mice either showed no change or minor decrease of cell proliferation. 
      TNF-R1 and TNF-R2 receptors were expressed by hippocampal progenitors, as 
      assessed with reverse transcription-PCR on sorted or cultured cells and 
      immunocytochemistry on cultures. Our data reveal differential actions of TNF-R1 
      and TNF-R2 signaling in adult hippocampal neurogenesis and identify for the first 
      time TNF-R1 as a negative regulator of neural progenitor proliferation in both 
      the intact and pathological brain.
FAU - Iosif, Robert E
AU  - Iosif RE
AD  - Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, 
      Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden.
FAU - Ekdahl, Christine T
AU  - Ekdahl CT
FAU - Ahlenius, Henrik
AU  - Ahlenius H
FAU - Pronk, Cornelis J H
AU  - Pronk CJ
FAU - Bonde, Sara
AU  - Bonde S
FAU - Kokaia, Zaal
AU  - Kokaia Z
FAU - Jacobsen, Sten-Eirik W
AU  - Jacobsen SE
FAU - Lindvall, Olle
AU  - Lindvall O
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Growth Inhibitors)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
SB  - IM
MH  - Animals
MH  - *Cell Proliferation
MH  - Cells, Cultured
MH  - Growth Inhibitors/genetics/*physiology
MH  - Hippocampus/*cytology/pathology/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Neurons/*cytology/metabolism/pathology
MH  - Receptors, Tumor Necrosis Factor, Type I/deficiency/genetics/*physiology
MH  - Receptors, Tumor Necrosis Factor, Type II/deficiency/physiology
MH  - Stem Cells/*cytology/*physiology
PMC - PMC6674454
EDAT- 2006/09/22 09:00
MHDA- 2006/10/14 09:00
PMCR- 2007/03/20
CRDT- 2006/09/22 09:00
PHST- 2006/09/22 09:00 [pubmed]
PHST- 2006/10/14 09:00 [medline]
PHST- 2006/09/22 09:00 [entrez]
PHST- 2007/03/20 00:00 [pmc-release]
AID - 26/38/9703 [pii]
AID - 3148851 [pii]
AID - 10.1523/JNEUROSCI.2723-06.2006 [doi]
PST - ppublish
SO  - J Neurosci. 2006 Sep 20;26(38):9703-12. doi: 10.1523/JNEUROSCI.2723-06.2006.