PMID- 16990829
OWN - NLM
STAT- MEDLINE
DCOM- 20061114
LR  - 20220316
IS  - 1745-834X (Print)
IS  - 1745-834X (Linking)
VI  - 2
IP  - 10
DP  - 2006 Oct
TI  - Therapy Insight: CNS manifestations of HIV-associated immune reconstitution 
      inflammatory syndrome.
PG  - 557-65
AB  - The introduction of combination antiretroviral therapy for HIV infection has 
      prolonged the lives of patients with AIDS. It is increasingly being recognized, 
      however, that following initiation of this therapy some patients can develop a 
      paradoxical neurological deterioration, despite dramatic improvements in HIV 
      viral load and CD4+ T-cell counts. This immune reconstitution inflammatory 
      syndrome (IRIS) in the CNS is emerging as an important neurological complication, 
      particularly as antiretroviral therapy is now becoming readily available 
      worldwide. Currently, there are no guidelines for prevention, diagnosis or 
      treatment of the CNS manifestations of IRIS. Even in patients with an acute 
      presentation, the diagnosis can be challenging. Furthermore, it is possible that 
      more-chronic forms of the syndrome exist but remain unrecognized. Here, we review 
      the various clinical presentations of CNS IRIS, and discuss options for their 
      management.
FAU - Riedel, David J
AU  - Riedel DJ
AD  - University of Maryland, Baltimore, MD 21287, USA.
FAU - Pardo, Carlos A
AU  - Pardo CA
FAU - McArthur, Justin
AU  - McArthur J
FAU - Nath, Avindra
AU  - Nath A
LA  - eng
GR  - R01NS039253/NS/NINDS NIH HHS/United States
GR  - K08DA016160/DA/NIDA NIH HHS/United States
GR  - K08 DA016160/DA/NIDA NIH HHS/United States
GR  - K08 DA016160-03/DA/NIDA NIH HHS/United States
GR  - P01MH70056/MH/NIMH NIH HHS/United States
GR  - P01MH070306/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Nat Clin Pract Neurol
JT  - Nature clinical practice. Neurology
JID - 101261799
SB  - IM
MH  - AIDS-Related Opportunistic Infections/complications
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Brain Diseases/*chemically induced/*diagnosis/immunology
MH  - HIV Infections/complications/*drug therapy
MH  - Humans
MH  - Inflammation
RF  - 62
EDAT- 2006/09/23 09:00
MHDA- 2006/11/15 09:00
CRDT- 2006/09/23 09:00
PHST- 2006/06/13 00:00 [received]
PHST- 2006/08/03 00:00 [accepted]
PHST- 2006/09/23 09:00 [pubmed]
PHST- 2006/11/15 09:00 [medline]
PHST- 2006/09/23 09:00 [entrez]
AID - ncpneuro0303 [pii]
AID - 10.1038/ncpneuro0303 [doi]
PST - ppublish
SO  - Nat Clin Pract Neurol. 2006 Oct;2(10):557-65. doi: 10.1038/ncpneuro0303.