PMID- 16997300
OWN - NLM
STAT- MEDLINE
DCOM- 20061219
LR  - 20071115
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 86
IP  - 6
DP  - 2006 Dec
TI  - Regulated upon activation, normal T cell expressed and secreted (RANTES) and 
      monocyte chemotactic protein 1 in follicular fluid accumulate differentially in 
      patients with and without endometriosis undergoing in vitro fertilization.
PG  - 1616-20
AB  - OBJECTIVE: To compare the amount of regulated upon activation, normal T cell 
      expressed and secreted (RANTES) and monocyte chemotactic protein 1 (MCP-1) in 
      follicular fluid (FF) of patients with and without endometriosis and to determine 
      their oocyte fertilization and pregnancy rates. DESIGN: Case-control study. 
      SETTING: Department of Obstetrics and Gynecology, University Hospital 
      Schleswig-Holstein, Campus Luebeck, Germany. PATIENT(S): Thirty-two women with 
      endometriosis stages I-IV and 28 women without endometriosis, both groups 
      surgically and histologically confirmed. INTERVENTION(S): Diagnostic laparoscopy, 
      IVF-ET. MAIN OUTCOME MEASURE(S): RANTES and MCP-1 levels in follicular fluid, 
      measured by ELISA, and oocyte fertilization and pregnancy rates. RESULT(S): 
      Follicular response and days of gonadotropin stimulation were similar between the 
      two groups. The levels of RANTES in FF from patients with endometriosis were 
      significantly higher (460.4 +/- 90.3 pg/mL) compared with concentrations in 
      patients with tubal infertility (243.8 +/- 70.9 pg/mL; P<.05). In contrast, MCP-1 
      concentrations in FF from women with endometriosis (330.0 +/- 29.2 pg/mL) were 
      lower than in women with tubal infertility (420.5 +/- 46.6 pg/mL; P<.05). Oocyte 
      fertilization rates in the endometriosis group (54%) were significantly lower 
      than those of the tubal infertility group (73%; P<.05), as were the pregnancy 
      rates (19% vs. 35%, respectively; P<.01). CONCLUSION(S): Women with 
      endometriosis-associated infertility have a poor IVF outcome. Immune cell 
      recruitment into the ovary might affect follicular function and lead to impaired 
      oocyte quality.
FAU - Xu, Hong
AU  - Xu H
AD  - Department of Gynecology and Obstetrics, University of Schleswig-Holstein, 
      Luebeck, Germany.
FAU - Schultze-Mosgau, Askan
AU  - Schultze-Mosgau A
FAU - Agic, Admir
AU  - Agic A
FAU - Diedrich, Klaus
AU  - Diedrich K
FAU - Taylor, Robert N
AU  - Taylor RN
FAU - Hornung, Daniela
AU  - Hornung D
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060925
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/*immunology
MH  - Chemokine CCL5/*immunology
MH  - Endometriosis/complications/*immunology
MH  - Female
MH  - *Fertilization in Vitro
MH  - Follicular Fluid/*immunology
MH  - Humans
MH  - Infertility, Female/etiology/*immunology/*therapy
MH  - Lymphocyte Activation/immunology
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - T-Lymphocytes/immunology
EDAT- 2006/09/26 09:00
MHDA- 2006/12/21 09:00
CRDT- 2006/09/26 09:00
PHST- 2005/12/27 00:00 [received]
PHST- 2006/05/11 00:00 [revised]
PHST- 2006/05/11 00:00 [accepted]
PHST- 2006/09/26 09:00 [pubmed]
PHST- 2006/12/21 09:00 [medline]
PHST- 2006/09/26 09:00 [entrez]
AID - S0015-0282(06)03057-3 [pii]
AID - 10.1016/j.fertnstert.2006.05.043 [doi]
PST - ppublish
SO  - Fertil Steril. 2006 Dec;86(6):1616-20. doi: 10.1016/j.fertnstert.2006.05.043. 
      Epub 2006 Sep 25.