PMID- 16997566
OWN - NLM
STAT- MEDLINE
DCOM- 20070201
LR  - 20220408
IS  - 1043-2760 (Print)
IS  - 1043-2760 (Linking)
VI  - 17
IP  - 9
DP  - 2006 Nov
TI  - Menin and its interacting proteins: elucidation of menin function.
PG  - 357-64
AB  - The multiple endocrine neoplasia type 1 (MEN1) gene is a tumor suppressor gene 
      encoding a 610 amino acid nuclear protein, menin. Although mutations of the MEN1 
      gene are responsible for MEN 1 syndrome, the intracellular functions of menin 
      have not been fully elucidated. Recent data suggest that interactions between 
      menin and menin-interacting proteins have a role in physiological regulation of 
      cell growth, control of the cell cycle and genome stability, and are potentially 
      important in bone development and multipotent mesenchymal stem cell 
      differentiation. Loss of these interactions might also contribute to the 
      development of MEN 1 syndrome.
FAU - Balogh, Katalin
AU  - Balogh K
AD  - Second Department of Medicine, Semmelweis University, Szentkiralyi str. 46, 
      H-1088 Budapest, Hungary. bkatus@freemail.hu
FAU - Racz, Karoly
AU  - Racz K
FAU - Patocs, Attila
AU  - Patocs A
FAU - Hunyady, Laszlo
AU  - Hunyady L
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060925
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Bone Development/physiology
MH  - Endocrine Gland Neoplasms/etiology/metabolism
MH  - Hematopoiesis/physiology
MH  - Humans
MH  - Models, Biological
MH  - Multiple Endocrine Neoplasia Type 1/genetics
MH  - Protein Binding
MH  - Proto-Oncogene Proteins/*metabolism/*physiology
RF  - 43
EDAT- 2006/09/26 09:00
MHDA- 2007/02/03 09:00
CRDT- 2006/09/26 09:00
PHST- 2006/06/07 00:00 [received]
PHST- 2006/08/25 00:00 [revised]
PHST- 2006/09/14 00:00 [accepted]
PHST- 2006/09/26 09:00 [pubmed]
PHST- 2007/02/03 09:00 [medline]
PHST- 2006/09/26 09:00 [entrez]
AID - S1043-2760(06)00175-5 [pii]
AID - 10.1016/j.tem.2006.09.004 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2006 Nov;17(9):357-64. doi: 10.1016/j.tem.2006.09.004. 
      Epub 2006 Sep 25.