PMID- 16999024
OWN - NLM
STAT- MEDLINE
DCOM- 20061106
LR  - 20131121
IS  - 0019-5189 (Print)
IS  - 0019-5189 (Linking)
VI  - 44
IP  - 9
DP  - 2006 Sep
TI  - Neuroprotective effect of BDNF in young and aged 6-OHDA treated rat model of 
      Parkinson disease.
PG  - 699-704
AB  - Brain derived neurotrophic factor (BDNF) has been shown to exert trophic effects 
      on dopaminergic neurons against 6-hydroxydopamine (6-OHDA) in young rat. Since 
      the degeneration of substantia nigra dopaminergic neurons that occurs in 
      Parkinson's disease is more often than not confined to elderly individuals, it is 
      of interest to determine whether the effects of BDNF against 6 hydroxydopamine 
      (6-OHDA) in young rats can be extended to aged animals. 6-hydroxydopamine was 
      stereotaxically injected into the striatum of young (3-months) and aged 
      (24-months) rats, which were treated two hours earlier with BDNF. 6-OHDA results 
      in almost complete destruction of substantia nigra pars compacta dopaminergic 
      neurons. BDNF injection significantly changed apomorphine induced rotations from 
      132 +/- 15 to 181 +/- 10, staircase test from 73 +/- 2% to 61 +/- 3%, initiation 
      time from 7 +/- 2 to 12 +/- 1 sec, and disengage time from 80 +/- 7 to 90 +/- 5 
      sec in young and aged animals, respectively. It is concluded that BDNF causes the 
      limited behavior recovery of striatal DA systems from 6-OHDA toxicity in aged 
      animals.
FAU - Singh, Shalini
AU  - Singh S
AD  - Department of Physiology, Maulana Azad Medical College, New Delhi, India.
FAU - Ahmad, Riyaz
AU  - Ahmad R
FAU - Mathur, Deepti
AU  - Mathur D
FAU - Sagar, Ravinder Kumar
AU  - Sagar RK
FAU - Krishana, Bal
AU  - Krishana B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian J Exp Biol
JT  - Indian journal of experimental biology
JID - 0233411
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 8HW4YBZ748 (Oxidopamine)
SB  - IM
MH  - Aging/*pathology
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/administration & dosage/*therapeutic use
MH  - Corpus Striatum/drug effects/pathology
MH  - Disease Models, Animal
MH  - Neuroprotective Agents/administration & dosage/*therapeutic use
MH  - Oxidopamine/*toxicity
MH  - Parkinson Disease/etiology/pathology/physiopathology/*prevention & control
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Substantia Nigra/drug effects/pathology
EDAT- 2006/09/27 09:00
MHDA- 2006/11/07 09:00
CRDT- 2006/09/27 09:00
PHST- 2006/09/27 09:00 [pubmed]
PHST- 2006/11/07 09:00 [medline]
PHST- 2006/09/27 09:00 [entrez]
PST - ppublish
SO  - Indian J Exp Biol. 2006 Sep;44(9):699-704.