PMID- 17001159
OWN - NLM
STAT- MEDLINE
DCOM- 20061026
LR  - 20151119
IS  - 0147-5185 (Print)
IS  - 0147-5185 (Linking)
VI  - 30
IP  - 10
DP  - 2006 Oct
TI  - Gastrointestinal involvement in mantle cell lymphoma: a prospective clinic, 
      endoscopic, and pathologic study.
PG  - 1274-80
AB  - The frequency of gastrointestinal (GI) tract involvement in mantle cell lymphoma 
      (MCL) at diagnosis is reported to be below 30%. To investigate the actual 
      frequency of GI involvement by MCL, upper and lower endoscopy was prospectively 
      performed on 13 untreated MCL patients at diagnosis. Multiple biopsies from 
      endoscopically normal and abnormal gastric and colonic mucosa were studied with 
      immunohistochemistry (IHC) for CD20, CD5, and cyclin D1, as well as fluorescence 
      in situ hybridization (FISH) for t(11;14) and polymerase chain reaction (PCR) for 
      immunoglobulin heavy chain gene. Abnormal mucosa was identified in 38% of cases 
      by upper endoscopy (mainly mild nonspecific gastritis) and in 54% of cases by 
      lower endoscopy (mostly micropolyps). Histologically, infiltration by MCL was 
      demonstrated in the stomach in 77% of cases and in the colon in 77% of cases. As 
      a whole, 92% of patients showed upper or lower GI tract infiltration by MCL. 
      Histologic evidence of MCL involvement was present in all cases with 
      endoscopically abnormal mucosa, but it was also observed in two-thirds of cases 
      with endoscopically unremarkable mucosa. Positive cyclin D1 IHC was seen in all 
      instances displaying CD20 and CD5-positive lymphoid infiltrates, whereas t(11;14) 
      was demonstrated by FISH in 63.5% and PCR was clonal in 64% of those instances. 
      In conclusion, the great majority of MCL patients showed GI tract involvement at 
      the time of diagnosis, not uncommonly in the form of minute lymphoid infiltrates. 
      IHC for cyclin D1 was significantly more sensitive than FISH t(11;14) or PCR for 
      immunoglobulin heavy chain gene to confirm MCL in this setting.
FAU - Salar, Antonio
AU  - Salar A
AD  - Department of Clinical Hematology, Hospital del Mar, Barcelona, Spain. 
      asalar@imas.imim.es
FAU - Juanpere, Nuria
AU  - Juanpere N
FAU - Bellosillo, Beatriz
AU  - Bellosillo B
FAU - Domingo-Domenech, Eva
AU  - Domingo-Domenech E
FAU - Espinet, Blanca
AU  - Espinet B
FAU - Seoane, Agustin
AU  - Seoane A
FAU - Romagosa, Vicente
AU  - Romagosa V
FAU - Gonzalez-Barca, Eva
AU  - Gonzalez-Barca E
FAU - Panades, Agustin
AU  - Panades A
FAU - Pedro, Carmen
AU  - Pedro C
FAU - Nieto, Miguel
AU  - Nieto M
FAU - Abella, Eugenia
AU  - Abella E
FAU - Sole, Francesc
AU  - Sole F
FAU - Ariza, Aurelio
AU  - Ariza A
FAU - Fernandez-Sevilla, Alberto
AU  - Fernandez-Sevilla A
FAU - Besses, Carlos
AU  - Besses C
FAU - Serrano, Sergio
AU  - Serrano S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Biomarkers, Tumor)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/metabolism
MH  - Bone Marrow Cells/pathology
MH  - Clone Cells
MH  - Cyclin D1/metabolism
MH  - *Endoscopy, Gastrointestinal
MH  - Female
MH  - Gastric Mucosa/metabolism/*pathology
MH  - Gastrointestinal Neoplasms/metabolism/*pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Intestinal Mucosa/metabolism/*pathology
MH  - Lymphoma, Mantle-Cell/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
EDAT- 2006/09/27 09:00
MHDA- 2006/10/27 09:00
CRDT- 2006/09/27 09:00
PHST- 2006/09/27 09:00 [pubmed]
PHST- 2006/10/27 09:00 [medline]
PHST- 2006/09/27 09:00 [entrez]
AID - 00000478-200610000-00010 [pii]
AID - 10.1097/01.pas.0000208899.15859.cb [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2006 Oct;30(10):1274-80. doi: 
      10.1097/01.pas.0000208899.15859.cb.