PMID- 17001223
OWN - NLM
STAT- MEDLINE
DCOM- 20070221
LR  - 20220316
IS  - 1741-8267 (Print)
IS  - 1741-8267 (Linking)
VI  - 13
IP  - 5
DP  - 2006 Oct
TI  - Effect of physical training on exercise capacity, gas exchange and N-terminal 
      pro-brain natriuretic peptide levels in patients with chronic heart failure.
PG  - 812-7
AB  - BACKGROUND: Decreased exercise capacity is the main factor restricting the daily 
      life of patients with chronic heart failure. N-terminal pro-brain natriuretic 
      peptide (NT pro-BNP) is strongly related to the severity of and is an independent 
      predictor of outcome in chronic heart failure. DESIGN: The study aimed to 
      evaluate the effect of exercise training on functional capacity and on changes in 
      NT pro-BNP levels and to assess the effect of exercise training on quality of 
      life. MATERIALS AND METHODS: Sixty patients (45 men/15 women, mean age 52.7 
      years; +/-5.3 SD), with stable heart failure (45 ischaemic/hypertensive and 15 
      idiopathic patients), in New York Heart Association (NYHA) functional class II 
      (n=35) to III (n=25), with an ejection fraction less than 40%, were randomly 
      assigned to a training (n=30) and a control group (n=30). The training group (30 
      patients) performed 3 months of supervised physical training programme using a 
      bicycle ergometer for 30 min three times a week at a load corresponding to 60-70% 
      of their oxygen consumption (VO2) peak. The control group did not change their 
      previous physical activity. A graded maximal exercise test with respiratory gas 
      analysis and an endurance test with constant workload corresponding to 85% of the 
      peak oxygen load at the baseline and after 3 months were performed, and at the 
      same times NT pro-BNP levels were measured. RESULTS: The exercise capacity 
      increased from 15.8 (+/-2.3 SD) to 29.9 (+/-2.1 SD) min (P<0.0001) and the peak 
      VO2 tended to improve from 14.5 (+/-1.4 SD) to 17.7 (+/-2.6 SD) ml/kg per min 
      (P<0.0001) during the supervised training period. VO2 at the anaerobic threshold 
      increased from 12.9 (+/-1.0 SD) to 15.5 (+/-1.7 SD) ml/kg per min (P<0.0001). NT 
      pro-BNP levels decreased from 3376 (+/-3133 SD) to 1434 (+/-1673 SD) pg/ml 
      (P=0.043). The positive training effects were associated with an improvement in 
      the NYHA functional class. CONCLUSION: Physical training of moderate intensity 
      significantly improves the exercise capacity and neurohormonal modulation in 
      patients with chronic heart failure. This is associated with an alleviation of 
      symptoms and improvement in quality of life.
FAU - Maria Sarullo, Filippo
AU  - Maria Sarullo F
AD  - Division of Cardiology bClinical Pathology Service, Buccheri La Ferla 
      Fatebenefratelli Hospital, Palermo, Italy. fsarullo@neomedia.it
FAU - Gristina, Tommaso
AU  - Gristina T
FAU - Brusca, Ignazio
AU  - Brusca I
FAU - Milia, Salvatore
AU  - Milia S
FAU - Raimondi, Raffaella
AU  - Raimondi R
FAU - Sajeva, Massimo
AU  - Sajeva M
FAU - Maria La Chiusa, Stella
AU  - Maria La Chiusa S
FAU - Serio, Gesualdo
AU  - Serio G
FAU - Paterna, Salvatore
AU  - Paterna S
FAU - Di Pasquale, Pietro
AU  - Di Pasquale P
FAU - Castello, Antonio
AU  - Castello A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Eur J Cardiovasc Prev Rehabil
JT  - European journal of cardiovascular prevention and rehabilitation : official 
      journal of the European Society of Cardiology, Working Groups on Epidemiology & 
      Prevention and Cardiac Rehabilitation and Exercise Physiology
JID - 101192000
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Exercise/*physiology
MH  - Female
MH  - Heart Failure/*metabolism/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*metabolism
MH  - Peptide Fragments/*metabolism
MH  - Physical Fitness/*physiology
MH  - Pulmonary Gas Exchange/*physiology
EDAT- 2006/09/27 09:00
MHDA- 2007/02/22 09:00
CRDT- 2006/09/27 09:00
PHST- 2006/09/27 09:00 [pubmed]
PHST- 2007/02/22 09:00 [medline]
PHST- 2006/09/27 09:00 [entrez]
AID - 00149831-200610000-00021 [pii]
AID - 10.1097/01.hjr.0000238396.42718.61 [doi]
PST - ppublish
SO  - Eur J Cardiovasc Prev Rehabil. 2006 Oct;13(5):812-7. doi: 
      10.1097/01.hjr.0000238396.42718.61.