PMID- 17002138
OWN - NLM
STAT- MEDLINE
DCOM- 20070531
LR  - 20091119
IS  - 1001-5515 (Print)
IS  - 1001-5515 (Linking)
VI  - 23
IP  - 4
DP  - 2006 Aug
TI  - [Ras-MAPK signaling pathway activated via brain-derived neurotrophic factor].
PG  - 915-8
AB  - Brain-derived neurotrophic factor (BDNF)is the richest neurophin in brain tissue 
      and may act as an activity-dependent neuronal survival factor. In vitro, BDNF 
      plays an important role in preventing cortical neurons from hypoxia-induced 
      neurotoxicity. It could induce a variety of cellular responses such as cell 
      growth, survival, differentiation, and anti-apoptosis mainly via activating 
      mitogen-activated protein kinase (MAPK) and Ca2+/calmodulin-dependent kinase 
      (CaMK) signaling pathways. And among these multiple signaling pathways there is 
      growing evidence of complicated cross talk.
FAU - Sun, Xiaomei
AU  - Sun X
AD  - West China Second University Hospital, Sichuan University, Chengdu 610041, China.
FAU - Mao, Meng
AU  - Mao M
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
JT  - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = 
      Shengwu yixue gongchengxue zazhi
JID - 9426398
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/pharmacology/*physiology
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2
MH  - Calcium-Calmodulin-Dependent Protein Kinases/drug effects/*physiology
MH  - Cells, Cultured
MH  - Humans
MH  - Mitogen-Activated Protein Kinases/drug effects/*physiology
MH  - Neurons/cytology/*drug effects/enzymology
MH  - *Signal Transduction
RF  - 21
EDAT- 2006/09/28 09:00
MHDA- 2007/06/01 09:00
CRDT- 2006/09/28 09:00
PHST- 2006/09/28 09:00 [pubmed]
PHST- 2007/06/01 09:00 [medline]
PHST- 2006/09/28 09:00 [entrez]
PST - ppublish
SO  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006 Aug;23(4):915-8.