PMID- 17002218
OWN - NLM
STAT- MEDLINE
DCOM- 20061019
LR  - 20220310
IS  - 1367-6733 (Print)
IS  - 1367-6733 (Linking)
VI  - 9
IP  - 5
DP  - 2006 Sep
TI  - Brain-derived neurotrophic factor mechanisms and function in adult synaptic 
      plasticity: new insights and implications for therapy.
PG  - 580-6
AB  - Synaptic plasticity, the fiundamental ability of synapses to undergo 
      experience-dependent changes in synaptic strength, is thought to underlie a range 
      of long-term adaptive responses of the central nervous system. The inability to 
      generate or maintain appropriate changes in synaptic connectivity and neuronal 
      circuitry is likely to impair cognitive futnction associated with many 
      neurological and psychiatric disorders. The success of intervening therapeutic 
      approaches will depend on the ability to target key component mechanisms in the 
      complex process of synaptic plasticity. Brain-derived neurotrophic factor (BDNF) 
      has emerged as a major regulator of synaptic plasticity and a key target in 
      disorders such as major depression and Alzheimner's disease. This review 
      discusses findings that link BDNF mechanisms in synaptic plasticity to disease 
      mechanisms and possible future therapies.
FAU - Kuipers, Sjoukje D
AU  - Kuipers SD
AD  - Department of Biomedicine and Bergen Mental Health Research Center, University of 
      Bergen, Jonas Lies vei 91, N-5009 Bergen, Norway.
FAU - Bramham, Clive R
AU  - Bramham CR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Curr Opin Drug Discov Devel
JT  - Current opinion in drug discovery & development
JID - 100887519
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nootropic Agents)
SB  - IM
MH  - Alzheimer Disease/drug therapy/physiopathology
MH  - Animals
MH  - Antidepressive Agents/therapeutic use
MH  - Brain/physiology
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Humans
MH  - Mood Disorders/drug therapy/physiopathology
MH  - Neuronal Plasticity/*physiology
MH  - Nootropic Agents/*pharmacology/therapeutic use
MH  - Synapses/*physiology
RF  - 90
EDAT- 2006/09/28 09:00
MHDA- 2006/10/20 09:00
CRDT- 2006/09/28 09:00
PHST- 2006/09/28 09:00 [pubmed]
PHST- 2006/10/20 09:00 [medline]
PHST- 2006/09/28 09:00 [entrez]
PST - ppublish
SO  - Curr Opin Drug Discov Devel. 2006 Sep;9(5):580-6.