PMID- 17002447
OWN - NLM
STAT- MEDLINE
DCOM- 20061124
LR  - 20131121
IS  - 0021-8561 (Print)
IS  - 0021-8561 (Linking)
VI  - 54
IP  - 20
DP  - 2006 Oct 4
TI  - Antioxidative effect of quercetin and its equimolar mixtures with phenyltin 
      compounds on liposome membranes.
PG  - 7735-46
AB  - Our earlier studies have shown that the compounds diphenyltin dichloride (DPhT) 
      and triphenyltin chloride (TPhT) in the presence of UVC radiation enhanced the 
      degree of phosphatidylcholine liposome membrane oxidation (J. Agric. Food Chem. 
      2005, 53, 76-83). The prooxidative behavior of the compounds has now been 
      confirmed with the electron paramagnetic resonance method, which proved the 
      possibility that the studied compounds can exist in free radical forms. The 
      present work investigates the possibility of the protective action of quercetin 
      on phosphatidylcholine liposome membranes exposed to the prooxidative action of 
      DPhT and TPhT induced by UV radiation (lambda = 253.7 nm). The concentrations of 
      quercetin and its equimolar mixtures with DPhT and TPhT were determined (and 
      compared with well-known antioxidants as standards-trolox and butylated 
      hydroxytoluene, also in the presence of phenyltins) as those that induce 50% 
      inhibition in oxidation of liposomes radiated with UV. They are 5.1 +/- 0.10, 2.9 
      +/- 0.12, and 1.9 +/- 0.08 microM (differences between the values are 
      statistically significant), constituting the following sequence of antioxidative 
      activity: quercetin:TPhT > quercetin:DPhT > quercetin. This relation is confirmed 
      by the results on the antiradical ability of quercetin and its mixtures with DPhT 
      and TPhT toward the free radical 1,1-diphenyl-2-pricrylhydrazil. Similar 
      sequences obtained in both studies suggest a possible mechanism of the 
      antiradical action of the mixtures as free radical scavengers. We suggested that 
      (i) quercetin's ability, documented by spectrophotometric, infrared attenuated 
      total reflectance spectroscopy, (1)H NMR, and molecular modeling methods, to form 
      complexes with phenyltins indicates a possible way of protection against the 
      peroxidation caused by the free radical forms of phenyltins and (ii) the 
      differentiation in the action of the quercetin/TPhT and quercetin/DPhT associates 
      (statisticaly significant) may result from a different localization in the 
      liposome membrane, which is indicated by the results of the fluorimetric studies.
FAU - Gabrielska, Janina
AU  - Gabrielska J
AD  - Department of Physics and Biophysics, Agricultural University, 50-375 Wroclaw, 
      Norwida 25, Poland. jaga@ozi.ar.wroc.pl
FAU - Soczynska-Kordala, Monika
AU  - Soczynska-Kordala M
FAU - Hladyszowski, Jerzy
AU  - Hladyszowski J
FAU - Zylka, Romuald
AU  - Zylka R
FAU - Miskiewicz, Janusz
AU  - Miskiewicz J
FAU - Przestalski, Stanislaw
AU  - Przestalski S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Antioxidants)
RN  - 0 (Chromans)
RN  - 0 (Glycerophospholipids)
RN  - 0 (Liposomes)
RN  - 0 (Organotin Compounds)
RN  - 0 (phosphatidylchromanol)
RN  - 1135-99-5 (diphenyltin chloride)
RN  - 2406-68-0 (phenyltin)
RN  - 9IKM0I5T1E (Quercetin)
RN  - I1L80IDY27 (triphenyltin chloride)
SB  - IM
MH  - Antioxidants/*pharmacology
MH  - Chromans
MH  - Electron Spin Resonance Spectroscopy
MH  - Glycerophospholipids
MH  - Lipid Peroxidation/*drug effects
MH  - *Liposomes
MH  - Models, Molecular
MH  - Organotin Compounds/chemistry/*pharmacology
MH  - Quercetin/chemistry/*pharmacology
EDAT- 2006/09/28 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/09/28 09:00
PHST- 2006/09/28 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/09/28 09:00 [entrez]
AID - 10.1021/jf060720a [doi]
PST - ppublish
SO  - J Agric Food Chem. 2006 Oct 4;54(20):7735-46. doi: 10.1021/jf060720a.