PMID- 17002682
OWN - NLM
STAT- MEDLINE
DCOM- 20061121
LR  - 20070813
IS  - 0906-6705 (Print)
IS  - 0906-6705 (Linking)
VI  - 15
IP  - 11
DP  - 2006 Nov
TI  - The 21st century renaissance of the basophil? Current insights into its role in 
      allergic responses and innate immunity.
PG  - 855-64
AB  - Basophils and mast cells express all the three subchains of the high-affinity 
      immunoglobulin E (IgE) receptor Fc epsilon RI and contain preformed histamine in 
      the cytoplasmic granules. However, it is increasingly clear that these cells play 
      distinct roles in allergic inflammatory disease. Despite their presence 
      throughout much of the animal kingdom, the physiological function of basophils 
      remains obscure. As rodent mast cells are more numerous than basophils, and 
      generate an assortment of inflammatory cytokines, basophils have often been 
      regarded as minor players in allergic inflammation. In humans, however, basophils 
      are the prime early producers of interleukin (IL)-4 and IL-13, T helper 
      (Th)2-type cytokines crucial for initiating and maintaining allergic responses. 
      Basophils also express CD40 ligand which, in combination with IL-4 and IL-13, 
      facilitates IgE class switching in B cells. They are the main cellular source for 
      early IL-4 production, which is vital for the development of Th2 responses. The 
      localization of basophils in various tissues affected by allergic inflammation 
      has now been clearly demonstrated by using specific staining techniques and the 
      new research is shedding light on their selective recruitment to the tissues. 
      Finally, recent studies have shown that basophil activation is not restricted to 
      antigen-specific IgE crosslinking, but can be caused in non-sensitized 
      individuals by a growing list of parasitic antigens, lectins and viral 
      superantigens, binding to non-specific IgE antibodies. This, together with novel 
      IgE-independent routes of activation, imparts important new insights into the 
      potential role of basophils in both adaptive and innate immunity.
FAU - Falcone, Franco H
AU  - Falcone FH
AD  - The School of Pharmacy, University of Nottingham, Nottingham, UK.
FAU - Zillikens, Detlef
AU  - Zillikens D
FAU - Gibbs, Bernhard F
AU  - Gibbs BF
LA  - eng
GR  - GR065978MA/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
SB  - IM
MH  - Animals
MH  - Basophils/*immunology
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immune System/*cytology/immunology
RF  - 85
EDAT- 2006/09/28 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/09/28 09:00
PHST- 2006/09/28 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/09/28 09:00 [entrez]
AID - EXD477 [pii]
AID - 10.1111/j.1600-0625.2006.00477.x [doi]
PST - ppublish
SO  - Exp Dermatol. 2006 Nov;15(11):855-64. doi: 10.1111/j.1600-0625.2006.00477.x.