PMID- 17002906
OWN - NLM
STAT- MEDLINE
DCOM- 20061114
LR  - 20061115
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 9
DP  - 2006 Sep
TI  - Association of HLA-DR and -DQ genes with narcolepsy in Koreans: comparison with 
      two control groups, randomly selected subjects and DRB1*1501-DQB1*0602--positive 
      subjects.
PG  - 749-55
AB  - The purpose of this study was to investigate the association of human leukocyte 
      antigen (HLA) class II alleles with narcolepsy-cataplexy susceptibility in 
      Koreans. The distribution of HLA-DRB1 and -DQB1 alleles and presence or absence 
      of DRB3/4/5 alleles were examined in 60 narcoleptic patients with clear-cut 
      cataplexy, and the results were compared with two groups of healthy controls: 200 
      randomly selected controls and 144 DRB1*1501-DQB1*0602 positive controls. All of 
      the narcoleptic patients were DRB1*1501 and DQB1*0602 positive, and their 
      frequencies were significantly higher in patients than in random controls (100% 
      vs 17.0%, p(c) = 2.3 x 10(-30), OR = 583.96; 100% vs 16.5%, p(c) = 3.9 x 10(-31), 
      OR = 605.00). The HLA association in Koreans was as tight as that reported in 
      Japanese. Several DRB1 (*0101, *0405, *0901) and DQB1 alleles (*0303, *0401, 
      *0501, *0601, *0604) were found to have weak protective effects against 
      narcolepsy. DRB4 showed strong protective effect, and this was also significant 
      when compared with DRB1*1501-DQB1*0602 positive controls (18.3% vs 44.4%, p(c) = 
      0.001, OR = 0.28). DRB3 (OR = 1.86) and DQB1*0301 (OR = 2.45) were found to have 
      weak predisposing effect, when compared with DRB1*1501-DQB1*0602 positive 
      controls. The protective effect of DRB4 has to be further studied in other 
      populations.
FAU - Roh, Eun Youn
AU  - Roh EY
AD  - Department of Laboratory Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Park, Myoung Hee
AU  - Park MH
FAU - Park, Hyejin
AU  - Park H
FAU - Park, Doo-Heum
AU  - Park DH
FAU - Choi, Jong-Bae
AU  - Choi JB
FAU - Kim, Seog Ju
AU  - Kim SJ
FAU - Jeong, Do-Un
AU  - Jeong DU
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060630
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cataplexy/*genetics
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Humans
MH  - Korea/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Narcolepsy/*genetics
MH  - Phenotype
MH  - Polymerase Chain Reaction
EDAT- 2006/09/28 09:00
MHDA- 2006/11/15 09:00
CRDT- 2006/09/28 09:00
PHST- 2005/09/29 00:00 [received]
PHST- 2006/03/20 00:00 [revised]
PHST- 2006/03/23 00:00 [accepted]
PHST- 2006/09/28 09:00 [pubmed]
PHST- 2006/11/15 09:00 [medline]
PHST- 2006/09/28 09:00 [entrez]
AID - S0198-8859(06)00153-4 [pii]
AID - 10.1016/j.humimm.2006.03.024 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Sep;67(9):749-55. doi: 10.1016/j.humimm.2006.03.024. Epub 2006 
      Jun 30.