PMID- 17003838
OWN - NLM
STAT- MEDLINE
DCOM- 20061222
LR  - 20131121
IS  - 1745-8323 (Print)
IS  - 1745-8323 (Linking)
VI  - 2
IP  - 10
DP  - 2006 Oct
TI  - Acute renal failure associated with immune restoration inflammatory syndrome.
PG  - 594-8; quiz 599
AB  - BACKGROUND: A 30-year-old HIV-infected woman presented with fever and abdominal 
      pain 4 days after initiation of highly active antiretroviral therapy (HAART), and 
      1 month after initiation of antimicrobial therapy for Mycobacterium tuberculosis 
      infection. A diagnosis of immune restoration inflammatory syndrome (IRIS) was 
      considered, and corticosteroids were started. Steroid therapy doses were 
      progressively tapered, during which time the patient developed renal failure with 
      enlarged kidneys. A renal biopsy showed acute interstitial nephritis. Extensive 
      investigations failed to detect active infection. The efficacy of HAART was 
      attested by increased CD4+ cell counts and undetectable viral replication. 
      INVESTIGATIONS: Physical examination, plasma viral load and CD4+ cell count, 
      abdominal and renal ultrasound, renal and peritoneal biopsies, renal and liver 
      function, chest X-ray, and bronchoalveolar lavage culture. DIAGNOSIS: Acute renal 
      failure secondary to IRIS. MANAGEMENT: Prednisone therapy.
FAU - Daugas, Eric
AU  - Daugas E
AD  - Department of Nephrology, Tenon Hospital, Paris, France.
FAU - Plaisier, Emmanuelle
AU  - Plaisier E
FAU - Boffa, Jean-Jacques
AU  - Boffa JJ
FAU - Guiard-Schmid, Jean-Baptiste
AU  - Guiard-Schmid JB
FAU - Pacanowski, Jerome
AU  - Pacanowski J
FAU - Mougenot, Beatrice
AU  - Mougenot B
FAU - Ronco, Pierre
AU  - Ronco P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Nat Clin Pract Nephrol
JT  - Nature clinical practice. Nephrology
JID - 101261800
RN  - 0 (Anti-Inflammatory Agents)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Acute Kidney Injury/drug therapy/*immunology/pathology/physiopathology
MH  - Adult
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Female
MH  - Humans
MH  - Immune System Diseases/*physiopathology
MH  - Prednisone/pharmacology
EDAT- 2006/09/28 09:00
MHDA- 2006/12/23 09:00
CRDT- 2006/09/28 09:00
PHST- 2005/09/27 00:00 [received]
PHST- 2006/06/08 00:00 [accepted]
PHST- 2006/09/28 09:00 [pubmed]
PHST- 2006/12/23 09:00 [medline]
PHST- 2006/09/28 09:00 [entrez]
AID - ncpneph0282 [pii]
AID - 10.1038/ncpneph0282 [doi]
PST - ppublish
SO  - Nat Clin Pract Nephrol. 2006 Oct;2(10):594-8; quiz 599. doi: 10.1038/ncpneph0282.