PMID- 17004042
OWN - NLM
STAT- MEDLINE
DCOM- 20070123
LR  - 20181113
IS  - 0165-7380 (Print)
IS  - 0165-7380 (Linking)
VI  - 30
IP  - 7
DP  - 2006 Oct
TI  - Chronic vanadium poisoning in calves and its treatment with calcium disodium 
      ethylenediaminetetraacetate.
PG  - 807-22
AB  - Sixteen Friesland heifer calves aged between 96 and 157 days were removed from a 
      dairy farm that had been polluted with vanadium and randomly allocated into two 
      equal groups (n = 8). The objective of the trial was to determine whether calcium 
      disodium ethylenediaminetetraacetate (CaNa(2)EDTA) could be used as a treatment 
      for cattle running in environments high in background vanadium. The treatment 
      group received 80 mg CaNa(2)EDTA per kg body weight intraperitonealy (i.p.) twice 
      a week over a 10-week period. The control group received normal saline i.p. over 
      the same period. During the trial calves were exposed to a daily intake of 
      vanadium in the form of contaminated tef hay derived from the farm of origin. In 
      addition, the total mixed ration was spiked with a further 20 mg V(2)O(5)/kg feed 
      to compensate for possible on-farm inhalation exposure. A stochastic model was 
      used to estimate daily intake of vanadium as a distribution function. The model 
      estimated that the daily intake of vanadium varied between an absolute minimum of 
      33 mg/day to an absolute maximum of 124 mg/day. The average intake of vanadium 
      was 71.8 mg per day per calf. Various chemical pathology parameters were measured 
      throughout the trial as well as urine excretion rates of vanadium and lymphocyte 
      stimulation counts. All calves were slaughtered and necropsied in cohorts of 4-6 
      animals at monthly intervals after completion of the trial and withdrawal of 
      vanadium from the ration. Tissue concentrations of vanadium were determined and 
      necropsy findings were noted. The study found that CaNa(2)EDTA appears to enhance 
      the excretion of vanadium in calves, but could not prove that the treatment had a 
      protective effect against vanadium exposure. Calves were able to tolerate the 
      prolonged treatment with CaNa(2)EDTA without side-effects.
FAU - Gummow, B
AU  - Gummow B
AD  - Department of Production Animal Studies, University of Pretoria, Onderstepoort, 
      South Africa. Bruce.Gummow@up.ac.za
FAU - Botha, C J
AU  - Botha CJ
FAU - Williams, M C
AU  - Williams MC
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Vet Res Commun
JT  - Veterinary research communications
JID - 8100520
RN  - 0 (Chelating Agents)
RN  - 0 (Trace Elements)
RN  - 00J9J9XKDE (Vanadium)
RN  - 9G34HU7RV0 (Edetic Acid)
SB  - IM
MH  - Animals
MH  - Body Burden
MH  - Cattle
MH  - Cattle Diseases/*drug therapy/metabolism
MH  - Chelating Agents/*therapeutic use
MH  - Chronic Disease
MH  - Edetic Acid/*therapeutic use
MH  - Female
MH  - Inhalation Exposure
MH  - Injections, Intraperitoneal/veterinary
MH  - Organ Specificity
MH  - Random Allocation
MH  - Stochastic Processes
MH  - Tissue Distribution
MH  - Trace Elements/metabolism/*toxicity/urine
MH  - Treatment Outcome
MH  - Urinalysis/veterinary
MH  - Vanadium/*metabolism/*toxicity/urine
EDAT- 2006/09/28 09:00
MHDA- 2007/01/24 09:00
CRDT- 2006/09/28 09:00
PHST- 2005/03/10 00:00 [accepted]
PHST- 2006/09/28 09:00 [pubmed]
PHST- 2007/01/24 09:00 [medline]
PHST- 2006/09/28 09:00 [entrez]
AID - 10.1007/s11259-006-3279-3 [doi]
PST - ppublish
SO  - Vet Res Commun. 2006 Oct;30(7):807-22. doi: 10.1007/s11259-006-3279-3.