PMID- 17006024
OWN - NLM
STAT- MEDLINE
DCOM- 20061019
LR  - 20190917
IS  - 0250-5991 (Print)
IS  - 0973-7138 (Electronic)
IS  - 0250-5991 (Linking)
VI  - 31
IP  - 3
DP  - 2006 Sep
TI  - Cyclic AMP response element binding protein and brain-derived neurotrophic 
      factor: molecules that modulate our mood?
PG  - 423-34
AB  - Depression is the major psychiatric ailment of our times, afflicting 
      approximately 20% of the population. Despite its prevalence, the pathophysiology 
      of this complex disorder is not well understood. In addition, although 
      antidepressants have been in existence for the past several decades, the 
      mechanisms that underlie their therapeutic effects remain elusive. Building 
      evidence implicates a role for the plasticity of specific neuro-circuitry in both 
      the pathophysiology and treatment of depression. Damage to limbic regions is 
      thought to contribute to the etiology of depression and antidepressants have been 
      reported to reverse such damage and promote adaptive plasticity. The molecular 
      pathways that contribute to the damage associated with depression and 
      antidepressant-mediated plasticity are a major focus of scientific enquiry. The 
      transcription factor cyclic AMP response element binding protein (CREB) and the 
      neurotrophin brain-derived neurotrophic factor (BDNF) are targets of diverse 
      classes of antidepressants and are known to be regulated in animal models and in 
      patients suffering from depression. Given their role in neuronal plasticity, CREB 
      and BDNF have emerged as molecules that may play an important role in modulating 
      mood. The purpose of this review is to discuss the role of CREB and BDNF in 
      depression and as targets/mediators of antidepressant action.
FAU - Nair, A
AU  - Nair A
AD  - Department of Biological Sciences, Tata Institute of Fundamental Research, Homi 
      Bhabha Road, Colaba, Mumbai 400 005, India.
FAU - Vaidya, V A
AU  - Vaidya VA
LA  - eng
GR  - 070048/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Review
PL  - India
TA  - J Biosci
JT  - Journal of biosciences
JID - 8100809
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
SB  - IM
MH  - *Affect
MH  - Animals
MH  - Antidepressive Agents/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology
MH  - Cyclic AMP Response Element-Binding Protein/genetics/*physiology
MH  - Depression/drug therapy/genetics/*metabolism
MH  - Gene Expression Regulation
MH  - Hippocampus/cytology/metabolism
MH  - Humans
MH  - Mice
MH  - Models, Animal
MH  - Mutation
MH  - Neuronal Plasticity/genetics/physiology
MH  - Rats
MH  - Signal Transduction
PMC - PMC4820646
MID - EMS31820
OID - NLM: EMS31820
EDAT- 2006/09/29 09:00
MHDA- 2006/10/20 09:00
PMCR- 2016/04/05
CRDT- 2006/09/29 09:00
PHST- 2006/09/29 09:00 [pubmed]
PHST- 2006/10/20 09:00 [medline]
PHST- 2006/09/29 09:00 [entrez]
PHST- 2016/04/05 00:00 [pmc-release]
AID - 10.1007/BF02704114 [doi]
PST - ppublish
SO  - J Biosci. 2006 Sep;31(3):423-34. doi: 10.1007/BF02704114.