PMID- 17007260
OWN - NLM
STAT- MEDLINE
DCOM- 20061026
LR  - 20131121
IS  - 1426-9686 (Print)
IS  - 1426-9686 (Linking)
VI  - 20
IP  - 120
DP  - 2006 Jun
TI  - [Estimation of the effect of lipoic acid in the rat's lung during 
      lipopolysaccharide-induced oxidative stress].
PG  - 651-4
AB  - The aim of this study was to investigate the effect of lipoic acid (LA) on lipid 
      peroxidation, hydrogen peroxide concentration (H2O2), sulphydryl group (-SH) 
      contents and total capacity protein a few hours after administration 
      lipopolysaccharide (LPS) -induced oxidative stress in rats. MATERIALS AND METODS: 
      Male albino Wistar rats were used in this study. The animals were divided into 
      four groups, each group consisting of ten male animals. Control group received 
      physiological saline alone i.v. The second group was given LA (60 mg/kg b.w., 
      i.v.). The third second group received LPS (30 mg/kg b.w., i.v.). The fourth 
      group received LPS (30 mg/kg b.w., i.v.) and after 0.5h received LA (60 mg/kg 
      b.w., i.v.). In the lung homogenates were measured thiobarbituric acid reactants 
      (TBARS), hydrogen peroxide concentration, -SH groups and protein contents. 
      RESULTS: The administration of LA after to LPS -induced oxidative stress caused a 
      significant decrease in TBARS and H2O2 concentrations (appropriate 3.65 +/- 0.2 
      microM and 0.014 +/- 0.008 microM) compared with the group treated with LPS 
      (appropriate 6.030 +/- 0.16 microM and 0.189 +/- 0.03 microM). Treatment of 
      LPS-injected rats with LA caused increase in -SH groups and protein concentration 
      (p < 0.05). CONCLUSION: The early administration of LA a significant decreased 
      symptoms of oxidative stress - induced LPS, that shows decrease in lipid 
      peroxidation process, H2O2 concentration and increase in -SH groups and protein 
      contents in rat's lung homogenates.
FAU - Skibska, Beata
AU  - Skibska B
AD  - Uniwersytet Medyczny w Lodzi, Katedra Fizjologii Doswiadczalnej i Klinicznej, 
      Zaklad Fizjologii Ukladu Krazenia.
FAU - Ciejka, Elzbieta
AU  - Ciejka E
FAU - Goraca, Anna
AU  - Goraca A
LA  - pol
PT  - English Abstract
PT  - Journal Article
TT  - Ocena dzialania kwasu liponowego w plucach szczura w czasie stresu oksydacyjnego 
      wywolanego lipopolisacharydem.
PL  - Poland
TA  - Pol Merkur Lekarski
JT  - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
JID - 9705469
RN  - 0 (Lipopolysaccharides)
RN  - 73Y7P0K73Y (Thioctic Acid)
SB  - IM
MH  - Animals
MH  - Lipid Peroxidation/drug effects
MH  - Lipopolysaccharides/*pharmacology
MH  - Lung/*drug effects
MH  - Male
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Thioctic Acid/administration & dosage/*pharmacology
EDAT- 2006/09/30 09:00
MHDA- 2006/10/27 09:00
CRDT- 2006/09/30 09:00
PHST- 2006/09/30 09:00 [pubmed]
PHST- 2006/10/27 09:00 [medline]
PHST- 2006/09/30 09:00 [entrez]
PST - ppublish
SO  - Pol Merkur Lekarski. 2006 Jun;20(120):651-4.