PMID- 17007384
OWN - NLM
STAT- MEDLINE
DCOM- 20110510
LR  - 20171116
IS  - 1673-0860 (Print)
IS  - 1673-0860 (Linking)
VI  - 41
IP  - 7
DP  - 2006 Jul
TI  - [Expressions and correlation with radiotherapy's effect of five kinds of genes in 
      nasopharyngeal carcinoma].
PG  - 542-5
AB  - OBJECTIVE: To investigate the expressions of E-cadherin, CD44H, matrix 
      metalloproteinase-3 (MMP-3), nm23H1 and vascular endothelial growth factor (VEGF) 
      in nasopharyngeal carcinoma and its relationship to the effect of radiotherapy. 
      Furthermore, to analyze the predict value of radiotherapy effect. METHODS: The 
      expressions of E-cadherin, CD44H, MMP-3, nm23H1 and VEGF in 62 patients with 
      nasopharyngeal carcinoma were determined by immunohistochemical SP method. There 
      were 62 patients (17 to 70 years old) with nasopharyngeal carcinoma which were 
      treated by radiotherapy from March 1995 to October 1995 and the period of 
      follow-up had full 10 years. RESULTS: The expressions of CD44H (chi2 = 18.739, P 
      = 0.028) and VEGF (chi2 = 18.523, P = 0.030) were closely related with short-term 
      effect after radiotherapy in nasopharyngeal carcinoma. The short-term effect was 
      descent along with enhancement of their expressions. In the group of low 
      expressions in CD44H and nm23H1, 3-year overall survival rate were 65.5% and 
      45.5%, and 5-year overall survival rate were 47.3% and 22.7%. In the group of 
      high expressions in CD44H and nm23H1, 3-year overall survival rate were 54.6% and 
      75.9%, and 5-year overall survival rate were 27.8% and 53.2%. There were 
      respectively significant difference between two group of expressions in CD44H 
      (chi2 = 7.31, P = 0.0069) and nm23H1 (chi2 = 15.64, P = 0.0001). CONCLUSIONS: 
      These findings indicated that to detect the expressions of CD44H and VEGF gene 
      may predict short-term effect of radiotherapy. Furthermore, to detect the 
      expressions of CD44H and nm23H1 gene may predict long-term effect of radiotherapy 
      in nasopharyngeal carcinoma.
FAU - Wang, Shuang-Le
AU  - Wang SL
AD  - Department of Otolaryngology Head and Neck Surgery, Shantou City Central 
      Hospital, Shantou 515031, China. Shuangle888@sohu.com
FAU - Huang, He-Cheng
AU  - Huang HC
FAU - Jiang, Yuan-Shi
AU  - Jiang YS
FAU - Yang, Qiang
AU  - Yang Q
LA  - chi
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of 
      otorhinolaryngology head and neck surgery
JID - 101247574
RN  - 0 (CD44 protein, human)
RN  - 0 (Cadherins)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (NM23 Nucleoside Diphosphate Kinases)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 2.7.4.6 (NME1 protein, human)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cadherins/genetics/metabolism
MH  - Carcinoma, Squamous Cell/genetics/*metabolism/radiotherapy
MH  - Female
MH  - Humans
MH  - Hyaluronan Receptors/genetics/metabolism
MH  - Male
MH  - Matrix Metalloproteinase 3/genetics/metabolism
MH  - Middle Aged
MH  - NM23 Nucleoside Diphosphate Kinases/genetics/metabolism
MH  - Nasopharyngeal Neoplasms/genetics/*metabolism/radiotherapy
MH  - Prognosis
MH  - Survival Rate
MH  - Treatment Outcome
MH  - Vascular Endothelial Growth Factor A/genetics/metabolism
MH  - Young Adult
EDAT- 2006/09/30 09:00
MHDA- 2011/05/11 06:00
CRDT- 2006/09/30 09:00
PHST- 2006/09/30 09:00 [pubmed]
PHST- 2011/05/11 06:00 [medline]
PHST- 2006/09/30 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2006 Jul;41(7):542-5.