PMID- 17008794
OWN - NLM
STAT- MEDLINE
DCOM- 20070329
LR  - 20161124
IS  - 0301-0163 (Print)
IS  - 0301-0163 (Linking)
VI  - 67
IP  - 1
DP  - 2007
TI  - Prevention and treatment of type 2 diabetes in youth.
PG  - 22-34
AB  - Parallel to the increase in obesity worldwide, there has been a rise in the 
      prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents. The 
      etiology of T2DM in youth, similar to adults, is multifactorial including genetic 
      and environmental factors, among them obesity, sedentary lifestyle, family 
      history of the disease, high-risk ethnicity and insulin resistance phenotype 
      playing major roles. Treatment of T2DM should not have a glucocentric approach; 
      it should rather target improving glycemia, dyslipidemia, hypertension, weight 
      management and the prevention of short- and long-term complications. Prevention 
      strategies, especially in high-risk groups, should focus on environmental change 
      involving participation of families, schools, the food and entertainment 
      industries and governmental agencies. Presently, limited pharmacotherapeutic 
      options need to be expanded both for childhood T2DM and obesity. The coming 
      decades will prove very challenging for healthcare providers battling 
      socioeconomic waves conducive to obesity and T2DM. Evidence-based research and 
      clinical experience in pediatrics, possibly modeled after adult trials, need to 
      be developed if this public health threat is to be contained.
CI  - Copyright (c) 2007 S. Karger AG, Basel.
FAU - Libman, Ingrid M
AU  - Libman IM
AD  - Division of Weight Management & Wellness, Children's Hospital of Pittsburgh, 
      Pittsburgh, PA 15213, USA.
FAU - Arslanian, Silva A
AU  - Arslanian SA
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060928
PL  - Switzerland
TA  - Horm Res
JT  - Hormone research
JID - 0366126
SB  - IM
MH  - Adolescent
MH  - Age of Onset
MH  - Diabetes Mellitus, Type 2/*epidemiology/*prevention & control/therapy
MH  - Humans
MH  - Obesity/complications/*epidemiology
MH  - Patient Care Planning
MH  - Risk Factors
MH  - United Kingdom/epidemiology
MH  - United States/epidemiology
RF  - 129
EDAT- 2006/09/30 09:00
MHDA- 2007/03/30 09:00
CRDT- 2006/09/30 09:00
PHST- 2006/09/30 09:00 [pubmed]
PHST- 2007/03/30 09:00 [medline]
PHST- 2006/09/30 09:00 [entrez]
AID - 95981 [pii]
AID - 10.1159/000095981 [doi]
PST - ppublish
SO  - Horm Res. 2007;67(1):22-34. doi: 10.1159/000095981. Epub 2006 Sep 28.