PMID- 17010262
OWN - NLM
STAT- MEDLINE
DCOM- 20070119
LR  - 20110913
IS  - 1330-027X (Print)
IS  - 1330-027X (Linking)
VI  - 14
IP  - 3
DP  - 2006
TI  - Serum levels of total immunoglobulin e in patients with alopecia areata: 
      relationship with clinical type of the disease.
PG  - 149-52
AB  - Alopecia areata (AA) is a heterogeneous disease characterized by nonscarring hair 
      loss on the scalp or any hair-bearing surface. A wide range of clinical 
      presentations can occur, from a single patch of hair loss to complete loss of 
      hair on the scalp (alopecia totalis, AT) or over the entire body (alopecia 
      universalis, AU). The cause of AA is unknown although most evidence supports the 
      hypothesis that AA is an immunologically mediated disease. The aim of the study 
      was to compare serum levels of total immunoglobulin E (IgE) between patients with 
      AA and healthy subjects, and to assess the difference between the localized form 
      and extensive forms of the disease such as AT and AU. Sixty patients with AA and 
      50 healthy subjects were enrolled in the study. Fifty patients had localized AA 
      (LAA), and ten patients had AT, AU or AT/AU. Serum levels of IgE were measured 
      using fluoroenzyme immunoassay techniques. Serum levels of total IgE were 
      significantly higher in AA patients than in controls (p<0.05). There was no 
      significant difference in serum levels of total IgE between patients with LAA and 
      those with extensive forms of the disease (p>0.05). The exact role of serum IgE 
      in AA should be additionally investigated in future studies.
FAU - Kasumagic-Halilovic, Emina
AU  - Kasumagic-Halilovic E
AD  - Department of Dermatovenereology Sarajevo University Clinical Center Bolnicka 28, 
      71000 Sarajevo, Bosnia and Herzegovina. kasumagicemina@yahoo.com
FAU - Prohic, Asja
AU  - Prohic A
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Acta Dermatovenerol Croat
JT  - Acta dermatovenerologica Croatica : ADC
JID - 9433781
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Alopecia Areata/*blood/pathology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
EDAT- 2006/10/03 09:00
MHDA- 2007/01/20 09:00
CRDT- 2006/10/03 09:00
PHST- 2006/10/03 09:00 [pubmed]
PHST- 2007/01/20 09:00 [medline]
PHST- 2006/10/03 09:00 [entrez]
PST - ppublish
SO  - Acta Dermatovenerol Croat. 2006;14(3):149-52.