PMID- 17010783 OWN - NLM STAT- MEDLINE DCOM- 20061228 LR - 20191210 IS - 0733-8635 (Print) IS - 0733-8635 (Linking) VI - 24 IP - 4 DP - 2006 Oct TI - Dermatologic manifestations of the immune reconstitution inflammatory syndrome. PG - 549-70, vii AB - The immune reconstitution inflammatory syndrome (IRIS) represents a diverse range of immunopathologic reactions resulting in clinical deterioration that may occur as immune function is partially restored in HIV-infected patients receiving highly active antiretroviral therapy. Approximately half of IRIS events are dermatologic, and dermatologic IRIS is described in relation to a wide range of conditions, the commonest being herpes zoster and herpes simplex. Most cases of IRIS result in mild and moderate symptoms, but non-dermatologic manifestations related to IRIS have resulted in death. This article covers certain general issues related to IRIS and then focuses on the spectrum of dermatologic manifestations. FAU - Lehloenya, Rannakoe AU - Lehloenya R AD - Division of Dermatology, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Observatory, 7925, South Africa. FAU - Meintjes, Graeme AU - Meintjes G LA - eng PT - Journal Article PT - Review PL - United States TA - Dermatol Clin JT - Dermatologic clinics JID - 8300886 SB - IM MH - Antiretroviral Therapy, Highly Active/*adverse effects MH - CD4 Lymphocyte Count MH - HIV/drug effects MH - HIV Infections/*drug therapy/immunology MH - Humans MH - Infections/etiology/immunology/microbiology MH - Inflammation MH - Skin Diseases/chemically induced/diagnosis/immunology MH - Syndrome MH - Viral Load RF - 130 EDAT- 2006/10/03 09:00 MHDA- 2006/12/29 09:00 CRDT- 2006/10/03 09:00 PHST- 2006/10/03 09:00 [pubmed] PHST- 2006/12/29 09:00 [medline] PHST- 2006/10/03 09:00 [entrez] AID - S0733-8635(06)00062-3 [pii] AID - 10.1016/j.det.2006.06.007 [doi] PST - ppublish SO - Dermatol Clin. 2006 Oct;24(4):549-70, vii. doi: 10.1016/j.det.2006.06.007.