PMID- 17010953
OWN - NLM
STAT- MEDLINE
DCOM- 20070212
LR  - 20220409
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1121
IP  - 1
DP  - 2006 Nov 22
TI  - Acute BDNF and cortisol response to low intensity exercise and following ramp 
      incremental exercise to exhaustion in humans.
PG  - 59-65
AB  - The effect of short-term aerobic exercise and a following ramp incremental cycle 
      ergometry to exhaustion on the acute response of the serum concentrations of 
      brain derived neurotrophic factor (BDNF) and cortisol (COR) was examined in 8 
      healthy male athletes. Venous and capillary blood samples were drawn at rest, 
      immediately after a 10 min warm-up period with aerobic exercise and after a ramp 
      test to exhaustion, as well as 3, 6, 10 and 15 min post exercise. Capillary blood 
      lactate (LA) concentration and blood gases as well as serum BDNF and COR 
      concentrations did not change during the warm-up period. LA was increased 
      (p<0.05) at the end of the ramp test and during recovery period while bicarbonate 
      concentration, carbon dioxide pressure, pH and base excess were decreased 
      (p<0.05) during this period. Serum BDNF was increased at the point of exhaustion 
      (p<0.05) while no significant differences were found between values at rest and 
      those during recovery period. At 10 and 15 min post incremental exercise, COR 
      concentrations were increased (p<0.05) compared to rest. The present study is the 
      first to demonstrate in humans that in contrast to short duration aerobic 
      exercise immediately after a following short duration high-intensity exercise to 
      exhaustion, there is a transient augmentation of serum BDNF concentration. 
      Short-term response of serum BDNF and COR concentrations differs as BDNF returns 
      to baseline level faster than COR.
FAU - Rojas Vega, Sandra
AU  - Rojas Vega S
AD  - Institute of Motor Control and Movement Technique, German Sport University 
      Cologne, Carl-Diem-Weg 6, 50933 Cologne, Germany. Rojas@dshs-koeln.de
FAU - Struder, Heiko K
AU  - Struder HK
FAU - Vera Wahrmann, Bertha
AU  - Vera Wahrmann B
FAU - Schmidt, Annette
AU  - Schmidt A
FAU - Bloch, Wilhelm
AU  - Bloch W
FAU - Hollmann, Wildor
AU  - Hollmann W
LA  - eng
PT  - Journal Article
DEP - 20060928
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 33X04XA5AT (Lactic Acid)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
EIN - Brain Res. 2007 Jul 2;1156:174-5
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Heat Exhaustion/*blood
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Lactic Acid/blood
MH  - Male
MH  - Sports
EDAT- 2006/10/03 09:00
MHDA- 2007/02/13 09:00
CRDT- 2006/10/03 09:00
PHST- 2006/04/03 00:00 [received]
PHST- 2006/08/23 00:00 [revised]
PHST- 2006/08/28 00:00 [accepted]
PHST- 2006/10/03 09:00 [pubmed]
PHST- 2007/02/13 09:00 [medline]
PHST- 2006/10/03 09:00 [entrez]
AID - S0006-8993(06)02654-0 [pii]
AID - 10.1016/j.brainres.2006.08.105 [doi]
PST - ppublish
SO  - Brain Res. 2006 Nov 22;1121(1):59-65. doi: 10.1016/j.brainres.2006.08.105. Epub 
      2006 Sep 28.