PMID- 17011530 OWN - NLM STAT- MEDLINE DCOM- 20070123 LR - 20061106 IS - 0006-8993 (Print) IS - 0006-8993 (Linking) VI - 1120 IP - 1 DP - 2006 Nov 20 TI - Transfer of accelerated presbycusis by transplantation of bone marrow cells from senescence-accelerated mice. PG - 93-9 AB - Until now, there has been no effective therapy for chronic sensorineural hearing impairment. This study investigated the role of bone marrow cells (BMCs) in cochlear dysfunction. BALB/c mice (2 months of age), a non-presbycusis-prone mouse strain, were lethally irradiated and then transplanted with BMCs from SAMP1 mice (2 months of age), a presbycusis-prone mouse strain. Acceleration of age-related hearing loss, early degeneration of spiral ganglion cells (SGCs) and impairment of immune function were observed in the recipient mice as well as in the SAMP1 mice. However, no spiral ganglion cells of donor (SAMP1) origin were detected in the recipient mice. These results indicated that accelerated presbycusis, cochlear pathology, and immune dysfunction of SAMP1 mice can be transferred to BALB/c recipient mice using allogeneic bone marrow transplantation (BMT). However, although the BMCs themselves cannot differentiate into the spiral ganglion cells (SGCs), they indirectly cause the degeneration of the SGCs. Further studies into the relationship between the inner ear cells and BMCs are required. FAU - Baba, Susumu AU - Baba S AD - Department of Otolaryngology, Kansai Medical University, 10-15 Fumizonocho, Moriguchi City, Osaka 570-8507, Japan. FAU - Iwai, Hiroshi AU - Iwai H FAU - Inaba, Muneo AU - Inaba M FAU - Kawamoto, Kohei AU - Kawamoto K FAU - Omae, Mariko AU - Omae M FAU - Yamashita, Toshio AU - Yamashita T FAU - Ikehara, Susumu AU - Ikehara S LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20061002 PL - Netherlands TA - Brain Res JT - Brain research JID - 0045503 SB - IM MH - Aging/*genetics MH - Animals MH - BALB 3T3 Cells MH - Bone Marrow Transplantation/immunology/*methods MH - Cell Count MH - Disease Models, Animal MH - Evoked Potentials, Auditory, Brain Stem/physiology MH - Fluorescent Antibody Technique/methods MH - Hearing Loss, Sensorineural/*genetics MH - Mice MH - Mice, Inbred BALB C MH - Mice, Inbred C57BL MH - Mice, Mutant Strains MH - Nerve Degeneration/genetics/pathology MH - Presbycusis/*etiology/immunology/pathology/physiopathology MH - Radiation Chimera MH - Spiral Ganglion/immunology/pathology/physiopathology EDAT- 2006/10/03 09:00 MHDA- 2007/01/24 09:00 CRDT- 2006/10/03 09:00 PHST- 2006/02/04 00:00 [received] PHST- 2006/08/04 00:00 [revised] PHST- 2006/08/22 00:00 [accepted] PHST- 2006/10/03 09:00 [pubmed] PHST- 2007/01/24 09:00 [medline] PHST- 2006/10/03 09:00 [entrez] AID - S0006-8993(06)02597-2 [pii] AID - 10.1016/j.brainres.2006.08.074 [doi] PST - ppublish SO - Brain Res. 2006 Nov 20;1120(1):93-9. doi: 10.1016/j.brainres.2006.08.074. Epub 2006 Oct 2.