PMID- 17011641
OWN - NLM
STAT- MEDLINE
DCOM- 20070611
LR  - 20131121
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 138
IP  - 2-3
DP  - 2007 Feb 1
TI  - Cardiovascular actions of central neuropeptide W in conscious rats.
PG  - 82-6
AB  - Neuropeptide W (NPW) is a novel hypothalamic peptide that activates the orphan G 
      protein-coupled receptors, GPR7 and GPR8. Two endogenous molecular forms of NPW 
      that consist of 23- and 30-amino acid residues were identified. 
      Intracerebroventricular (i.c.v.) administration of NPW is known to suppress 
      spontaneous-feeding at dark-phase and fasting-induced food intake and to decrease 
      body weight and plasma growth hormone and to increase prolactin and 
      corticosterone; however, little is known about its effect on other physiological 
      functions. We examined the effects of i.c.v. administration of NPW30 (0.3 and 3 
      nmol) on the mean arterial pressure (MAP), heart rate (HR), and plasma 
      norepinephrine and epinephrine in conscious rats. NPW30 (3 nmol) provoked 
      increases in MAP (85.12+/-3.16 to 106.26+/-2.66 mm Hg) and HR (305.75+/-13.76 to 
      428.45+/-26.82 beats/min) and plasma norepinephrine (138.1+/-18.1 to 297.2+/-25.9 
      pg/ml) and epinephrine (194.6+/-21.4 to 274.6+/-22.7 pg/ml). Intravenously 
      administered NPW30 (3 nmol) had no significant effects on MAP and HR. These 
      results indicate that central NPW30 increases sympathetic nervous outflow and 
      affects cardiovascular function.
FAU - Yu, Nanshou
AU  - Yu N
AD  - Department of Physiology, Faculty of Medicine, University of Miyazaki 5200 
      Kihara, Kiyotake-cho, Miyazaki-gun, Miyazaki 889-1692, Japan.
FAU - Chu, Chunping
AU  - Chu C
FAU - Kunitake, Takato
AU  - Kunitake T
FAU - Kato, Kazuo
AU  - Kato K
FAU - Nakazato, Masamitsu
AU  - Nakazato M
FAU - Kannan, Hiroshi
AU  - Kannan H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061002
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Catecholamines)
RN  - 0 (Neuropeptides)
RN  - 0 (neuropeptide W, rat)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Animals
MH  - Cardiovascular Physiological Phenomena/*drug effects
MH  - Catecholamines/blood
MH  - Consciousness
MH  - Dose-Response Relationship, Drug
MH  - Epinephrine/blood
MH  - Heart Rate/drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Neuropeptides/administration & dosage/*pharmacology
MH  - Norepinephrine/blood
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
EDAT- 2006/10/03 09:00
MHDA- 2007/06/15 09:00
CRDT- 2006/10/03 09:00
PHST- 2006/02/06 00:00 [received]
PHST- 2006/08/06 00:00 [revised]
PHST- 2006/08/07 00:00 [accepted]
PHST- 2006/10/03 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2006/10/03 09:00 [entrez]
AID - S0167-0115(06)00154-6 [pii]
AID - 10.1016/j.regpep.2006.08.003 [doi]
PST - ppublish
SO  - Regul Pept. 2007 Feb 1;138(2-3):82-6. doi: 10.1016/j.regpep.2006.08.003. Epub 
      2006 Oct 2.