PMID- 17011988
OWN - NLM
STAT- MEDLINE
DCOM- 20061218
LR  - 20061002
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 170
IP  - 2
DP  - 2006 Oct 15
TI  - Primary mediastinal (thymic) large B-cell lymphoma with a der(14)t(8;14)(q24;q32) 
      and a translocation of MYC to the derivative chromosome 14 with a deleted IgH 
      locus.
PG  - 158-62
AB  - We report a case of primary mediastinal (thymic) large B-cell lymphoma (PMBL) 
      with an initial karyotype containing numerical chromosomal aberrations: +X, +9, 
      +12, +21, and a novel translocation t(2;11)(q?31; q23 approximately 24) with a 
      duplication of the derivative chromosome 11. Subsequent multicolor fluorescence 
      in situ hybridization (M-FISH) analysis revealed a der(14)t(8;14)(q24;q32). 
      Further analysis using fluorescence in situ hybridization (FISH) with 
      locus-specific probes revealed loss of the entire IgH locus from the 
      der(14)t(8;14) and relocation of MYC to this derivative chromosome 14. Our data 
      show definitively the existence of the t(8;14) in PMBL, previously only 
      suspected. This finding supplies additional evidence that a 
      translocation-mediated MYC activation may be an important event in the 
      pathogenesis of this unique lymphoma.
FAU - Stejskalova, Eva
AU  - Stejskalova E
AD  - Department of Pediatric Hematology and Oncology, University Hospital 
      Motol-Prague, Prague 5 - Motol, Czech Republic. eva.stejskalova@lfmotol.cuni.cz
FAU - Jarosova, Marie
AU  - Jarosova M
FAU - Kabickova, Edita
AU  - Kabickova E
FAU - Smelhaus, Vratislav
AU  - Smelhaus V
FAU - Mrhalova, Marcela
AU  - Mrhalova M
FAU - Kodet, Roman
AU  - Kodet R
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adolescent
MH  - Chromosome Aberrations
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 14
MH  - *Genes, Immunoglobulin Heavy Chain
MH  - *Genes, myc
MH  - Humans
MH  - Lymphoma, B-Cell/*genetics
MH  - Male
MH  - Mediastinal Neoplasms/*genetics
MH  - *Translocation, Genetic
EDAT- 2006/10/03 09:00
MHDA- 2006/12/19 09:00
CRDT- 2006/10/03 09:00
PHST- 2005/12/01 00:00 [received]
PHST- 2006/04/13 00:00 [revised]
PHST- 2006/04/21 00:00 [accepted]
PHST- 2006/10/03 09:00 [pubmed]
PHST- 2006/12/19 09:00 [medline]
PHST- 2006/10/03 09:00 [entrez]
AID - S0165-4608(06)00311-6 [pii]
AID - 10.1016/j.cancergencyto.2006.04.015 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2006 Oct 15;170(2):158-62. doi: 
      10.1016/j.cancergencyto.2006.04.015.