PMID- 17012654
OWN - NLM
STAT- MEDLINE
DCOM- 20070308
LR  - 20180724
IS  - 0007-1250 (Print)
IS  - 0007-1250 (Linking)
VI  - 189
DP  - 2006 Oct
TI  - Brain-derived neurotrophic factor (BDNF) gene and rapid-cycling bipolar disorder: 
      family-based association study.
PG  - 317-23
AB  - BACKGROUND: We have previously reported the Val66Met and GT(n) repeat 
      polymorphisms of the brain-derived neurotrophic factor (BDNF) gene to be 
      associated with bipolar disorder. However, these findings have not been 
      replicated consistently. AIMS: To dissect the association of the BDNF gene with 
      bipolar disorder by examining additional markers at the DNA level and by testing 
      the illness categories of bipolar disorder I and II and rapid cycling. METHOD: We 
      performed a family-based association study and haplotype analyses with 312 
      nuclear families using four single nucleotide polymorphisms (SNPs) and the 
      Val66Met and GT(n) repeat polymorphisms. RESULTS: The SNPs hCV11592756 and 
      rs2049045, the Val66Met and GT(n) were significantly associated with bipolar 
      disorder using transmission disequilibrium analyses (P=0.02, 0.009, 0.001 and 
      0.008 respectively). The effect atthese markers was mainly driven by the 
      rapid-cycling patients. CONCLUSIONS: Within bipolar disorder, variation in the 
      BDNF gene appears to predict risk for developing rapid cycling according to 
      DSM-IV. Incorporating this clinical sub-phenotyping into other studies of the 
      BDNF gene may help to resolve some of the inconsistencies reported thus far 
      concerning BDNF and bipolar disorder.
FAU - Muller, Daniel J
AU  - Muller DJ
AD  - Neurogenetics Section, Centre for Addiction and Mental Health Department of 
      Psychiatry, University of Toronto, 250 College Street R30, Toronto, Ontario 
      M5T1R8, Canada.
FAU - de Luca, Vincenzo
AU  - de Luca V
FAU - Sicard, Tricia
AU  - Sicard T
FAU - King, Nicole
AU  - King N
FAU - Strauss, John
AU  - Strauss J
FAU - Kennedy, James L
AU  - Kennedy JL
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Psychiatry
JT  - The British journal of psychiatry : the journal of mental science
JID - 0342367
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Family
MH  - Female
MH  - Genetic Markers/genetics
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Pedigree
MH  - Polymorphism, Genetic/*genetics
EDAT- 2006/10/03 09:00
MHDA- 2007/03/09 09:00
CRDT- 2006/10/03 09:00
PHST- 2006/10/03 09:00 [pubmed]
PHST- 2007/03/09 09:00 [medline]
PHST- 2006/10/03 09:00 [entrez]
AID - S0007125000170758 [pii]
AID - 10.1192/bjp.bp.105.010587 [doi]
PST - ppublish
SO  - Br J Psychiatry. 2006 Oct;189:317-23. doi: 10.1192/bjp.bp.105.010587.