PMID- 1701370
OWN - NLM
STAT- MEDLINE
DCOM- 19910124
LR  - 20190813
IS  - 0300-0664 (Print)
IS  - 0300-0664 (Linking)
VI  - 33
IP  - 3
DP  - 1990 Sep
TI  - Decreased sex hormone binding globulin (SHBG) and insulin-like growth factor 
      binding protein (IGFBP-1) in extreme obesity.
PG  - 415-22
AB  - Obesity may be characterized by abnormal sex steroid secretion and reduced sex 
      hormone binding globulin (SHBG) which in turn is related to fat distribution and 
      insulin secretion. Recent in-vitro and in-vivo evidence suggests that insulin is 
      the common mechanism regulating the secretion of SHBG and insulin-like growth 
      factor small binding protein (IGFBP-1). IGFBP-1 appears not only to be a carrier 
      for insulin growth factors (IGFs) but also to play an active role in growth 
      processes, independent of growth hormone secretion. We have examined the possible 
      relationship between fasting insulin, SHBG, testosterone, IGF-1, IGFBP-1 and fat 
      distribution in 25 extremely obese, menstruating women (mean weight 107 +/- 3 kg) 
      with normal glucose tolerance. Fat distribution was assessed from measurements of 
      the waist to hip ratio (W/H). The obese women showed an elevated fasting insulin 
      (mean +/- SEM; 21 +/- 2 mumol/l), a normal IGF-1, but reduced IGFBP-1 (14.6 +/- 2 
      micrograms/l); in 15 women IGFBP-1 levels were undetectable by the present assay. 
      In addition, SHBG levels were reduced in the obese women (24 +/- 2 nmol/l) but 
      total testosterone values (1.9 +/- 0.1 nmol/l) were normal. The elevated fasting 
      insulin levels were positively correlated with increasing upper segment obesity 
      as expressed by a rising W/H ratio (P less than 0.01, r2 = 0.306) and inversely 
      correlated with SHBG (P less than 0.01, r2 = 0.483). Similarly, reduced SHBG 
      values showed an inverse correlation with increasing W/H ratio (P less than 
      0.001, r2 = 0.383). No correlation was found between IGFBP-1 and W/H ratio but a 
      strong positive correlation was seen between IGFBP-1 and SHBG (P less than 0.001, 
      r2 = 0.466). Furthermore, an equally significant inverse correlation was found 
      between IGFBP-1 and insulin levels (P less than 0.001, r2 = 0.474).(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Weaver, J U
AU  - Weaver JU
AD  - Medical Unit, London Hospital, UK.
FAU - Holly, J M
AU  - Holly JM
FAU - Kopelman, P G
AU  - Kopelman PG
FAU - Noonan, K
AU  - Noonan K
FAU - Giadom, C G
AU  - Giadom CG
FAU - White, N
AU  - White N
FAU - Virdee, S
AU  - Virdee S
FAU - Wass, J A
AU  - Wass JA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Carrier Proteins)
RN  - 0 (Insulin)
RN  - 0 (Insulin-Like Growth Factor Binding Proteins)
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 0 (Somatomedins)
RN  - 3XMK78S47O (Testosterone)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Adult
MH  - Carrier Proteins/*blood
MH  - Female
MH  - Humans
MH  - Insulin/blood/*physiology
MH  - Insulin-Like Growth Factor Binding Proteins
MH  - Insulin-Like Growth Factor I/analysis
MH  - Obesity/*blood
MH  - Sex Hormone-Binding Globulin/*metabolism
MH  - Somatomedins/*analysis
MH  - Testosterone/blood
EDAT- 1990/09/01 00:00
MHDA- 1990/09/01 00:01
CRDT- 1990/09/01 00:00
PHST- 1990/09/01 00:00 [pubmed]
PHST- 1990/09/01 00:01 [medline]
PHST- 1990/09/01 00:00 [entrez]
AID - 10.1111/j.1365-2265.1990.tb00507.x [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 1990 Sep;33(3):415-22. doi: 
      10.1111/j.1365-2265.1990.tb00507.x.