PMID- 17013727
OWN - NLM
STAT- MEDLINE
DCOM- 20070330
LR  - 20061002
IS  - 0944-1166 (Print)
IS  - 0944-1166 (Linking)
VI  - 13
IP  - 5
DP  - 2006
TI  - Primary peripancreatic lymph node gastrinoma in a woman with MEN1.
PG  - 477-81
AB  - A 39-year-old woman was admitted to hospital due to perforated relapsing duodenal 
      ulcer. Clinical, laboratory, and surgical examinations revealed a peripancreatic 
      lymph node gastrinoma as the cause of Zollinger-Ellison syndrome. Further 
      examinations established multiple endocrine neoplasia type 1 (MEN1) with a 
      germline mutation at codon 1153 (T->A) in exon 7, causing an amino-acid change, 
      from isoleucine to asparagine (Ile348Asn), in the MEN1 gene. The following 
      findings strongly supported a diagnosis of primary lymph node gastrinoma: a rapid 
      fall of the serum gastrin level after operation, the continuous normalization of 
      the serum gastrin level before and after secretin stimulation, the lack of any 
      symptoms, and the absence of another tumor for 13 years after surgical resection 
      of the tumor-bearing lymph node. A review of similar cases in the world 
      literature reveals that not all gastrinomas in lymph nodes are the result of 
      metastastic spread. A long-term symptom-free follow-up after the excision of a 
      lymphnode gastrinoma is the only reliable criterion for the diagnosis of a 
      primary lymph node tumor. To our knowledge, this is the only well-documented case 
      of a primary lymph node gastrinoma in a patient with MEN1. Our case supports the 
      idea that any gastrinoma in patients with MEN1 should be surgically resected for 
      cure if possible.
FAU - Zhou, Hui
AU  - Zhou H
AD  - Department of Pathology, University of Bonn, Sigmund-Freud-Str. 25, D-53127, 
      Bonn, Germany.
FAU - Schweikert, Hans-Udo
AU  - Schweikert HU
FAU - Wolff, Martin
AU  - Wolff M
FAU - Fischer, Hans-Peter
AU  - Fischer HP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - J Hepatobiliary Pancreat Surg
JT  - Journal of hepato-biliary-pancreatic surgery
JID - 9431940
SB  - IM
MH  - Adult
MH  - Female
MH  - Gastrinoma
MH  - Humans
MH  - Lymphoma/*pathology
MH  - Multiple Endocrine Neoplasia Type 1/*pathology
MH  - Pancreas
MH  - Zollinger-Ellison Syndrome/pathology
RF  - 39
EDAT- 2006/10/03 09:00
MHDA- 2007/03/31 09:00
CRDT- 2006/10/03 09:00
PHST- 2005/01/06 00:00 [received]
PHST- 2006/02/24 00:00 [accepted]
PHST- 2006/10/03 09:00 [pubmed]
PHST- 2007/03/31 09:00 [medline]
PHST- 2006/10/03 09:00 [entrez]
AID - 10.1007/s00534-006-1111-7 [doi]
PST - ppublish
SO  - J Hepatobiliary Pancreat Surg. 2006;13(5):477-81. doi: 10.1007/s00534-006-1111-7.