PMID- 17013777
OWN - NLM
STAT- MEDLINE
DCOM- 20061222
LR  - 20160707
IS  - 1436-9990 (Print)
IS  - 1436-9990 (Linking)
VI  - 49
IP  - 10
DP  - 2006 Oct
TI  - [Research into the human genome driven by improved methods].
PG  - 989-94
AB  - The enormous progress made by research of the human genome is mainly driven by 
      newly established or improved methods for the analysis of nucleic acids and 
      proteins. Among the methods that have gained a wide-spread use within a 
      comparably short time are fluorescence in situ hybridization (FISH), polymerase 
      chain reaction (PCR) including methods for quantitative PCR, and the use of short 
      interfering RNA (siRNA) molecules aimed at gene silencing. The increasing 
      significance of the analysis of secondary modifications of nucleic acids and 
      proteins (genomic imprinting by DNA methylation, posttranslational protein 
      modification) is reflected by an increasing use of mass spectrometry for the 
      analysis and characterization of these biomolecules. Overall, in the future the 
      research into the human genome and the interpretation of data will further 
      benefit from these and other refined tools.
FAU - Bullerdiek, J
AU  - Bullerdiek J
AD  - Zentrum fur Humangenetik, Universitat Bremen, Leobener Strasse ZHG, 28359 Bremen, 
      BRD. bullerd@uni-bremen.de
LA  - ger
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Moderne Methoden in der Genomforschung und Humangenetik: Beispiele und 
      Anwendungsbereiche.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - DNA Methylation
MH  - Disease Models, Animal
MH  - Forecasting
MH  - Gene Silencing
MH  - *Genetic Research
MH  - *Genome, Human
MH  - Genomic Imprinting
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Mass Spectrometry
MH  - Medical Oncology/*methods
MH  - Mice
MH  - Mice, Knockout
MH  - Neoplasms/*genetics
MH  - Oligonucleotide Array Sequence Analysis
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Reverse Transcriptase Polymerase Chain Reaction
RF  - 39
EDAT- 2006/10/03 09:00
MHDA- 2006/12/23 09:00
CRDT- 2006/10/03 09:00
PHST- 2006/10/03 09:00 [pubmed]
PHST- 2006/12/23 09:00 [medline]
PHST- 2006/10/03 09:00 [entrez]
AID - 10.1007/s00103-006-0044-2 [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2006 
      Oct;49(10):989-94. doi: 10.1007/s00103-006-0044-2.