PMID- 17014264
OWN - NLM
STAT- MEDLINE
DCOM- 20061215
LR  - 20131121
IS  - 0735-7044 (Print)
IS  - 0735-7044 (Linking)
VI  - 120
IP  - 5
DP  - 2006 Oct
TI  - Conditioning following repeated exposure to MDMA in rats: role in the maintenance 
      of MDMA self-administration.
PG  - 1144-50
AB  - There has been some controversy in the literature concerning the ability of 
      +/-3,4 methylenedioxymethamphetamine (MDMA) to reinforce operant responding in 
      rats. In the present study, operant responding maintained by intravenous MDMA 
      infusions increased when the fixed ratio schedule was increased from 1 to 5, 
      decreased when saline was substituted for MDMA, and increased again when MDMA was 
      reintroduced. During self-administration training, each infusion of MDMA was 
      paired with the illumination of a light stimulus. The role of the continued 
      presentation of this drug-associated stimulus in operant responding was measured 
      in groups of rats that had received comparable exposure (average 19 daily test 
      sessions) to MDMA during training. When either the light stimulus or the drug 
      infusion was omitted, operant responding decreased gradually over the 15-day test 
      period following training. When both the light stimulus and the MDMA infusion 
      were omitted, there was a dramatic decrease in operant responding that persisted 
      for the entire 15-day test period. These findings suggest that cues associated 
      with MDMA develop conditioned properties that might contribute to drug taking.
FAU - Daniela, Evangeline
AU  - Daniela E
AD  - School of Psychology, Victoria University of Wellington, Wellington, New Zealand.
FAU - Gittings, David
AU  - Gittings D
FAU - Schenk, Susan
AU  - Schenk S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Amphetamine-Related Disorders/*psychology
MH  - Animals
MH  - Association Learning/drug effects
MH  - Conditioning, Operant/*drug effects
MH  - Cues
MH  - *Hallucinogens
MH  - Injections, Intravenous
MH  - Male
MH  - Motivation
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Photic Stimulation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Self Administration
EDAT- 2006/10/04 09:00
MHDA- 2006/12/16 09:00
CRDT- 2006/10/04 09:00
PHST- 2006/10/04 09:00 [pubmed]
PHST- 2006/12/16 09:00 [medline]
PHST- 2006/10/04 09:00 [entrez]
AID - 2006-12871-015 [pii]
AID - 10.1037/0735-7044.120.5.1144 [doi]
PST - ppublish
SO  - Behav Neurosci. 2006 Oct;120(5):1144-50. doi: 10.1037/0735-7044.120.5.1144.