PMID- 17014624
OWN - NLM
STAT- MEDLINE
DCOM- 20070201
LR  - 20221207
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 17
IP  - 7
DP  - 2006 Nov
TI  - Genetic association study between mbl2 and asthma phenotypes in Chinese children.
PG  - 501-7
AB  - Mannose-binding lectin (MBL), a member of the innate immune system, initiates 
      complement deposition on microbial surfaces. MBL deficiency is associated with 
      severe respiratory infections. Polymorphisms in the MBL gene (mbl2) were 
      associated with the susceptibility and severity of autoimmune diseases. This 
      study investigated whether mbl2 polymorphisms at positions -550 and -221 and at 
      codon-54 are associated with asthma phenotypes in Chinese children. Asthmatics 
      aged 5-18 yr and non-allergic controls were eligible, and their plasma total and 
      allergen-specific immunoglobulin E (IgE) concentrations were measured by 
      micro-particle immunoassay and fluorescent enzyme immunoassay. mbl2 polymorphisms 
      were genotyped by restriction fragment length polymorphism. Three hundred and 
      seventeen asthmatic children and 140 controls were recruited, with their mean 
      (s.d.) log-transformed plasma total IgE being 2.61 (0.61) and 1.77 (0.77), 
      respectively (p < 0.0001). Polymorphisms at -550 and codon-54 (p < 0.0001 for 
      both) but not at -221 (p = 0.534) of mbl2 were significantly associated with 
      plasma MBL concentrations. mbl2 genotypes were not associated with asthma, atopy, 
      sensitization to individual aeroallergens or spirometric variable. Subjects with 
      LYB haplotype had the lowest plasma MBL concentrations (p < 0.0001), but two- and 
      three-loci mbl2 haplotypes were also not associated with asthma diagnosis. 
      However, patients with LY and LYB haplotypes were less likely to be atopic (p = 
      0.006 and 0.031). Subjects with LY and LYA were also less likely to be sensitized 
      to cockroach (p = 0.035 and 0.047). The latter three associations became 
      insignificant when adjusted for multiple comparisons. Despite the importance of 
      MBL in innate immunity, our mbl2 polymorphisms only show weak association with 
      asthma and atopy in children.
FAU - Leung, Ting Fan
AU  - Leung TF
AD  - Department of Paediatrics, The Chinese Univesity of Hong Kong, Prince of Wales 
      Hospital, Hong Kong. tfleung@cuhk.edu.hk
FAU - Tang, Nelson L S
AU  - Tang NL
FAU - Sung, Ying Man
AU  - Sung YM
FAU - Li, Chung Yi
AU  - Li CY
FAU - Ma, Suk Ling
AU  - Ma SL
FAU - Lam, Christopher W K
AU  - Lam CW
FAU - Wong, Gary W K
AU  - Wong GW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 0 (MBL2 protein, human)
RN  - 0 (Mannose-Binding Lectin)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/immunology
MH  - Asian People/*genetics
MH  - Asthma/blood/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Haplotypes
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Male
MH  - Mannose-Binding Lectin/blood/*genetics
MH  - Phenotype
MH  - Polymorphism, Restriction Fragment Length
MH  - Polymorphism, Single Nucleotide
EDAT- 2006/10/04 09:00
MHDA- 2007/02/03 09:00
CRDT- 2006/10/04 09:00
PHST- 2006/10/04 09:00 [pubmed]
PHST- 2007/02/03 09:00 [medline]
PHST- 2006/10/04 09:00 [entrez]
AID - PAI446 [pii]
AID - 10.1111/j.1399-3038.2006.00446.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2006 Nov;17(7):501-7. doi: 
      10.1111/j.1399-3038.2006.00446.x.