PMID- 17014924
OWN - NLM
STAT- MEDLINE
DCOM- 20070820
LR  - 20070319
IS  - 0168-8227 (Print)
IS  - 0168-8227 (Linking)
VI  - 76
IP  - 2
DP  - 2007 May
TI  - Transforming growth factor-beta 1 levels in women with prior history of 
      gestational diabetes mellitus.
PG  - 193-8
AB  - It is known that women with prior history of gestational diabetes mellitus (pGDM) 
      feature obesity, insulin resistance and endothelial dysfunction which cause 
      premature atherosclerosis. Transforming growth factor-beta 1 (TGF-beta1) is a key 
      cytokine in obesity and insulin resistance and also play important roles in the 
      development of atherosclerosis. This study was conducted to demonstrate the serum 
      TGF-beta1 levels of people with pGDM. Thirty women with pGDM, 20 women with type 
      2 diabetes mellitus (T2DM) and 20 healthy women were enrolled. Serum TGF-beta1 
      levels of people with pGDM were found to be significantly higher than healthy 
      controls and significantly lower than women with T2DM. TGF-beta1 levels were 
      found to be correlated with postprandial glucose and age and inversely correlated 
      with body mass index (BMI) and waist circumference. On multiple regression 
      analysis postprandial glucose level, age and BMI were determined as the most 
      important factors affecting TGF-beta1 levels. This study demonstrates elevated 
      TGF-beta1 levels in pGDM. The inflammatory response to hyperglycemia and insulin 
      resistance could be the major factors for the increased expression of TGF-beta1.
FAU - Yener, S
AU  - Yener S
AD  - Dokuz Eylul University, School of Medicine, Department of Internal Medicine, 
      Division of Endocrinology and Metabolism, Izmir, Turkey. serkan.yener@deu.edu.tr
FAU - Demir, T
AU  - Demir T
FAU - Akinci, B
AU  - Akinci B
FAU - Bayraktar, F
AU  - Bayraktar F
FAU - Kebapcilar, L
AU  - Kebapcilar L
FAU - Ozcan, M A
AU  - Ozcan MA
FAU - Biberoglu, S
AU  - Biberoglu S
FAU - Yesil, S
AU  - Yesil S
LA  - eng
PT  - Journal Article
DEP - 20061002
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Body Mass Index
MH  - Diabetes, Gestational/*blood
MH  - Female
MH  - Humans
MH  - Hyperglycemia/blood
MH  - Insulin Resistance
MH  - Middle Aged
MH  - Obesity/blood
MH  - Pregnancy
MH  - Regression Analysis
MH  - Transforming Growth Factor beta1/*blood
EDAT- 2006/10/04 09:00
MHDA- 2007/08/21 09:00
CRDT- 2006/10/04 09:00
PHST- 2006/07/14 00:00 [received]
PHST- 2006/08/24 00:00 [revised]
PHST- 2006/08/29 00:00 [accepted]
PHST- 2006/10/04 09:00 [pubmed]
PHST- 2007/08/21 09:00 [medline]
PHST- 2006/10/04 09:00 [entrez]
AID - S0168-8227(06)00382-2 [pii]
AID - 10.1016/j.diabres.2006.08.014 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2007 May;76(2):193-8. doi: 
      10.1016/j.diabres.2006.08.014. Epub 2006 Oct 2.