PMID- 17015012
OWN - NLM
STAT- MEDLINE
DCOM- 20070131
LR  - 20141120
IS  - 0959-440X (Print)
IS  - 0959-440X (Linking)
VI  - 16
IP  - 6
DP  - 2006 Dec
TI  - Soluble guanylate cyclase.
PG  - 736-43
AB  - Soluble guanylate cyclase (sGC) is a mammalian nitric oxide (NO) sensor. When NO 
      binds to the sGC heme, its GTP cyclase activity markedly increases, thus 
      generating cyclic GMP, which serves to regulate several cell signaling functions. 
      A good deal is known about the kinetics and equilibrium of binding of NO to sGC, 
      leading to a proposed multistep mechanism of sGC activation that involves at 
      least two NO-binding sites. The crystal structure of a member of a recently 
      discovered family of prokaryotic sGC homologues has provided important insights 
      into structure-function relationships within the sGC family of proteins.
FAU - Poulos, Thomas L
AU  - Poulos TL
AD  - Department of Molecular Biology & Biochemistry, University of California Irvine, 
      Irvine, CA 92697-3900, USA. poulos@uci.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20061002
PL  - England
TA  - Curr Opin Struct Biol
JT  - Current opinion in structural biology
JID - 9107784
RN  - 0 (Ligands)
RN  - 0 (Recombinant Proteins)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 42VZT0U6YR (Heme)
RN  - EC 4.6.1.2 (Guanylate Cyclase)
SB  - IM
MH  - Animals
MH  - Enzyme Activation
MH  - Guanylate Cyclase/*chemistry/*metabolism
MH  - Heme/chemistry
MH  - In Vitro Techniques
MH  - Kinetics
MH  - Ligands
MH  - Models, Molecular
MH  - Nitric Oxide/metabolism
MH  - Prokaryotic Cells
MH  - Recombinant Proteins/chemistry/metabolism
MH  - Signal Transduction
MH  - Solubility
RF  - 29
EDAT- 2006/10/04 09:00
MHDA- 2007/02/01 09:00
CRDT- 2006/10/04 09:00
PHST- 2006/07/22 00:00 [received]
PHST- 2006/09/04 00:00 [revised]
PHST- 2006/09/21 00:00 [accepted]
PHST- 2006/10/04 09:00 [pubmed]
PHST- 2007/02/01 09:00 [medline]
PHST- 2006/10/04 09:00 [entrez]
AID - S0959-440X(06)00166-7 [pii]
AID - 10.1016/j.sbi.2006.09.006 [doi]
PST - ppublish
SO  - Curr Opin Struct Biol. 2006 Dec;16(6):736-43. doi: 10.1016/j.sbi.2006.09.006. 
      Epub 2006 Oct 2.