PMID- 17016617
OWN - NLM
STAT- MEDLINE
DCOM- 20070109
LR  - 20061003
IS  - 1107-3756 (Print)
IS  - 1107-3756 (Linking)
VI  - 18
IP  - 5
DP  - 2006 Nov
TI  - Genetic risk for atherothrombotic cerebral infarction in individuals stratified 
      by sex or conventional risk factors for atherosclerosis.
PG  - 871-83
AB  - The aim of the present study was to assess the genetic risk for atherothrombotic 
      cerebral infarction (ACI) in men and women separately as well as in individuals 
      with or without conventional risk factors for atherosclerosis and thereby to 
      contribute to the personalized prevention of ACI. The study population comprised 
      2705 unrelated Japanese individuals (1244 men, 1461 women), including 636 
      subjects (372 men, 264 women) with ACI. Subjects with ACI and controls either had 
      or did not have conventional risk factors for atherosclerosis, including 
      hypertension, hypercholesterolemia, and diabetes mellitus. The genotypes for 202 
      polymorphisms of 152 candidate genes were determined by a method that combines 
      polymerase chain reaction and sequence-specific oligonucleotide probes with 
      suspension array technology. Multivariable logistic regression analysis and a 
      stepwise forward selection procedure revealed that 11 different polymorphisms 
      were significantly (P < 0.005) associated with ACI in women or men or in 
      individuals with or without hyper-tension, hypercholesterolemia, or diabetes 
      mellitus: the 584C-->T polymorphism of LIPG, 5665G-->T of EDN1, and G-->A of 
      CCL11 in women; 677C-->T of MTHFR, 1323C-->T of ITGB2, 3932T-->C of APOE, and 
      -231A-->G of EDNRA in men; -572 G -->C of IL6 in hypertensive individuals; 
      -403G-->A of CCL5 and G-->A of COMT in individuals with hypercholesterolemia; and 
      3932T--> C of APOE and A-->G of TNFSF4 in diabetic individuals. Polymorphisms 
      associated with ACI may thus differ between women and men as well as among 
      individuals with different risk factors. Stratification of subjects on the basis 
      of sex or conventional risk factors for atherosclerosis may therefore be 
      important in order to achieve the personalized prevention of ACI with the use of 
      genetic information.
FAU - Yamaguchi, Sachiyo
AU  - Yamaguchi S
AD  - Department of Human Functional Genomics, Life Science Research Center, Mie 
      University, Mie 514-8507, Japan.
FAU - Yamada, Yoshiji
AU  - Yamada Y
FAU - Metoki, Norifumi
AU  - Metoki N
FAU - Yoshida, Hidemi
AU  - Yoshida H
FAU - Satoh, Kei
AU  - Satoh K
FAU - Ichihara, Sahoko
AU  - Ichihara S
FAU - Kato, Kimihiko
AU  - Kato K
FAU - Kameyama, Takashi
AU  - Kameyama T
FAU - Yokoi, Kiyoshi
AU  - Yokoi K
FAU - Matsuo, Hitoshi
AU  - Matsuo H
FAU - Segawa, Tomonori
AU  - Segawa T
FAU - Watanabe, Sachiro
AU  - Watanabe S
FAU - Nozawa, Yoshinori
AU  - Nozawa Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Int J Mol Med
JT  - International journal of molecular medicine
JID - 9810955
SB  - IM
MH  - Aged
MH  - Atherosclerosis/*complications/genetics
MH  - Cerebral Infarction/*genetics
MH  - Diabetes Mellitus/genetics
MH  - Female
MH  - Humans
MH  - Hypercholesterolemia/genetics
MH  - Intracranial Thrombosis/*complications/genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - Sex Factors
EDAT- 2006/10/04 09:00
MHDA- 2007/01/11 09:00
CRDT- 2006/10/04 09:00
PHST- 2006/10/04 09:00 [pubmed]
PHST- 2007/01/11 09:00 [medline]
PHST- 2006/10/04 09:00 [entrez]
PST - ppublish
SO  - Int J Mol Med. 2006 Nov;18(5):871-83.