PMID- 17016821
OWN - NLM
STAT- MEDLINE
DCOM- 20061221
LR  - 20221207
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 119
IP  - 12
DP  - 2006 Dec 15
TI  - HLA-class II haplotype associations with ovarian cancer.
PG  - 2980-5
AB  - The development of cancer is a multistep process that is characterized by the 
      accumulation of genetic alterations in cells and changed cellular interactions 
      with the surrounding healthy tissues. The human immune system is believed to be 
      intrinsically involved in this process. The correlation of certain human 
      leukocyte antigen (HLA)-class I and II haplotypes with tumorigenesis is 
      documented in a variety of tumors. However, few data exist on the possible 
      association of specific HLA-class II alleles or haplotypes with ovarian cancer. 
      In our sample of 52 Caucasian patients with primary ovarian carcinoma and 239 
      female healthy local controls, we observed a significantly increased incidence of 
      the HLA-class II haplotypes DRB1*0301 - DQA1*0501 - DQB1*0201 (p < 0.001) and 
      DRB1*1001 - DQA1*0101 - DQB1*0501 (p < 0.001) in the patients. Our data suggest 
      that HLA-class II loci or individual HLA-class II haplotypes may be involved in 
      the pathogenesis of ovarian cancer.
CI  - Copyright 2006 Wiley-Liss, Inc.
FAU - Kubler, Kirsten
AU  - Kubler K
AD  - Department of Obstetrics and Gynecology, University of Bonn, Sigmund Freud 
      Strasse 25, 53127 Bonn, Germany.
FAU - Arndt, Peter F
AU  - Arndt PF
FAU - Wardelmann, Eva
AU  - Wardelmann E
FAU - Krebs, Dieter
AU  - Krebs D
FAU - Kuhn, Walther
AU  - Kuhn W
FAU - van der Ven, Katrin
AU  - van der Ven K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Middle Aged
MH  - Ovarian Neoplasms/genetics/*pathology
MH  - White People/genetics
EDAT- 2006/10/04 09:00
MHDA- 2006/12/22 09:00
CRDT- 2006/10/04 09:00
PHST- 2006/10/04 09:00 [pubmed]
PHST- 2006/12/22 09:00 [medline]
PHST- 2006/10/04 09:00 [entrez]
AID - 10.1002/ijc.22266 [doi]
PST - ppublish
SO  - Int J Cancer. 2006 Dec 15;119(12):2980-5. doi: 10.1002/ijc.22266.