PMID- 17017834
OWN - NLM
STAT- MEDLINE
DCOM- 20061106
LR  - 20190902
IS  - 0160-6689 (Print)
IS  - 0160-6689 (Linking)
VI  - 67
IP  - 9
DP  - 2006 Sep
TI  - Possible link between childhood separation anxiety and adulthood personality 
      disorder in patients with anxiety disorders in Japan.
PG  - 1451-7
AB  - OBJECTIVE: The aim of this study was to examine whether childhood separation 
      anxiety symptoms associate with adulthood anxiety disorders or personality 
      disorders. METHOD: Separation Anxiety Symptom Inventory (SASI), Structured 
      Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II), and Global 
      Assessment of Functioning (GAF) were administered to 134 outpatients with anxiety 
      disorders and SASI was administered to 176 healthy volunteers (controls) 
      recruited in Japan from April 1999 through November 2003. RESULTS: SASI scores 
      were not correlated with age or sex in controls. In contrast, SASI scores were 
      higher in patients with anxiety disorders than in controls, especially in women. 
      SASI showed good test-retest reliability (Pearson correlation coefficient = 0.8). 
      One hundred thirteen patients (84.3%) had no comorbid anxiety disorder while 21 
      (15.7%) had any, and those with comorbid anxiety disorder tended to show higher 
      SASI scores (p = .053). In total, 60 (44.8%) of 134 patients had at least 1 
      personality disorder, and the most frequent disorders were from cluster C 
      (36.6%). The subgroup with comorbid personality disorders showed earlier onset (p 
      < .01), higher SASI scores (p < .01), and poorer recovery of global functioning 
      (p < .05) than the noncomorbid subgroup. Stepwise multiple regression analysis 
      revealed that SASI scores were higher in female (p < .05) and younger (p < .01) 
      patients and most strongly correlated with number of comorbid personality 
      disorders in adulthood (p < .01). CONCLUSION: These results suggest that there is 
      a continuum of anxiety disorders from childhood to adulthood, the severity of 
      separation anxiety appears to increase the risk of severe anxious-fearful 
      personality disorders in adulthood, and those with severe separation anxiety, 
      particularly females, may progress to suffer from comorbid adult anxiety 
      disorders.
FAU - Osone, Akira
AU  - Osone A
AD  - Department of Psychiatry, Tokyo Women's Medical University, Tokyo, Japan. 
      aosone@psy.twmu.ac.jp
FAU - Takahashi, Saburo
AU  - Takahashi S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Clin Psychiatry
JT  - The Journal of clinical psychiatry
JID - 7801243
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Age of Onset
MH  - Aged
MH  - Anxiety Disorders/*diagnosis/*epidemiology/psychology
MH  - Anxiety, Separation/*diagnosis/*epidemiology/psychology
MH  - Comorbidity
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Personality Disorders/*diagnosis/*epidemiology/psychology
MH  - Personality Inventory
MH  - Psychiatric Status Rating Scales/statistics & numerical data
MH  - Psychometrics
MH  - Regression Analysis
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Sex Factors
MH  - Surveys and Questionnaires
EDAT- 2006/10/05 09:00
MHDA- 2006/11/07 09:00
CRDT- 2006/10/05 09:00
PHST- 2006/10/05 09:00 [pubmed]
PHST- 2006/11/07 09:00 [medline]
PHST- 2006/10/05 09:00 [entrez]
AID - 10.4088/jcp.v67n0918 [doi]
PST - ppublish
SO  - J Clin Psychiatry. 2006 Sep;67(9):1451-7. doi: 10.4088/jcp.v67n0918.