PMID- 17018156
OWN - NLM
STAT- MEDLINE
DCOM- 20061103
LR  - 20230415
IS  - 1471-2105 (Electronic)
IS  - 1471-2105 (Linking)
VI  - 7
DP  - 2006 Oct 4
TI  - Development of an open source laboratory information management system for 2-D 
      gel electrophoresis-based proteomics workflow.
PG  - 430
AB  - BACKGROUND: In the post-genome era, most research scientists working in the field 
      of proteomics are confronted with difficulties in management of large volumes of 
      data, which they are required to keep in formats suitable for subsequent data 
      mining. Therefore, a well-developed open source laboratory information management 
      system (LIMS) should be available for their proteomics research studies. RESULTS: 
      We developed an open source LIMS appropriately customized for 2-D gel 
      electrophoresis-based proteomics workflow. The main features of its design are 
      compactness, flexibility and connectivity to public databases. It supports the 
      handling of data imported from mass spectrometry software and 2-D gel image 
      analysis software. The LIMS is equipped with the same input interface for 2-D gel 
      information as a clickable map on public 2DPAGE databases. The LIMS allows 
      researchers to follow their own experimental procedures by reviewing the 
      illustrations of 2-D gel maps and well layouts on the digestion plates and MS 
      sample plates. CONCLUSION: Our new open source LIMS is now available as a basic 
      model for proteome informatics, and is accessible for further improvement. We 
      hope that many research scientists working in the field of proteomics will 
      evaluate our LIMS and suggest ways in which it can be improved.
FAU - Morisawa, Hiraku
AU  - Morisawa H
AD  - Proteomics Collaboration Center, Tokyo Metropolitan Institute of Gerontology, 
      35-2 Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan. hmori@tmig.or.jp
FAU - Hirota, Mikako
AU  - Hirota M
FAU - Toda, Tosifusa
AU  - Toda T
LA  - eng
PT  - Journal Article
DEP - 20061004
PL  - England
TA  - BMC Bioinformatics
JT  - BMC bioinformatics
JID - 100965194
SB  - IM
MH  - Computational Biology/methods
MH  - Computer Graphics
MH  - *Database Management Systems
MH  - *Databases, Protein
MH  - Electrophoresis, Gel, Two-Dimensional/*methods
MH  - Information Dissemination/methods
MH  - Information Storage and Retrieval/*methods
MH  - Internet
MH  - Laboratories
MH  - Peptide Mapping/methods
MH  - Proteomics/*methods
MH  - *Software
MH  - *User-Computer Interface
PMC - PMC1599757
EDAT- 2006/10/05 09:00
MHDA- 2006/11/04 09:00
PMCR- 2006/10/04
CRDT- 2006/10/05 09:00
PHST- 2006/04/16 00:00 [received]
PHST- 2006/10/04 00:00 [accepted]
PHST- 2006/10/05 09:00 [pubmed]
PHST- 2006/11/04 09:00 [medline]
PHST- 2006/10/05 09:00 [entrez]
PHST- 2006/10/04 00:00 [pmc-release]
AID - 1471-2105-7-430 [pii]
AID - 10.1186/1471-2105-7-430 [doi]
PST - epublish
SO  - BMC Bioinformatics. 2006 Oct 4;7:430. doi: 10.1186/1471-2105-7-430.