PMID- 17018652
OWN - NLM
STAT- MEDLINE
DCOM- 20070125
LR  - 20151119
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 91
IP  - 12
DP  - 2006 Dec
TI  - Adiponectin concentration in umbilical cord serum is positively associated with 
      the weight ratio of fetus to placenta.
PG  - 5090-4
AB  - CONTEXT: Adiponectin (APN) concentration in umbilical cord serum is higher than 
      that in adult serum. Except for the positive association between birth weight and 
      cord APN concentration, little is known about the pathophysiological function of 
      APN in fetal development. OBJECTIVE: The objective of this study was to evaluate 
      the relationship of cord serum APN and IGF-I concentrations with the development 
      of the fetoplacental unit. DESIGN AND METHODS: Umbilical cord serum APN and IGF-I 
      concentrations were measured in term singleton deliveries (n = 94). The 
      association of cord APN and IGF-I concentrations was evaluated in relation to 
      fetal weight, placental weight, and fetoplacental (F/P) weight ratio. RESULTS: 
      Mean concentrations and sd of APN and IGF-I were 36.1 +/- 14.0 microg/ml and 58.6 
      +/- 27.0 ng/ml, respectively. Cord APN concentration was positively associated 
      with F/P weight ratio (r = 0.375, P < 0.001) as well as fetal weight (r = 0.389, 
      P < 0.001) but not placental weight. Cord IGF-I concentration was positively 
      associated with fetal weight (r = 0.405, P < 0.001) and placental weight (r = 
      0.400, P < 0.001) but not F/P weight ratio. In multiregression analysis, only APN 
      concentration resulted in a significant determinant of F/P weight ratio among 
      variables (beta = 0.376, P < 0.001). CONCLUSIONS: In cord hyperadiponectinemia, 
      fetuses tend to be disproportionately larger for their placental weight and vice 
      versa in cord hypoadiponectinemia. APN is shown to be the first biomarker 
      positively associated with F/P weight ratio.
FAU - Kadowaki, Kozo
AU  - Kadowaki K
AD  - Department of Obstetrics, Osaka Medical Center and Research Institute for 
      Maternal and Child Health, 840 Izumi, Osaka 594-1101, Japan. kozo1223@aol.com
FAU - Waguri, Masako
AU  - Waguri M
FAU - Nakanishi, Isao
AU  - Nakanishi I
FAU - Miyashita, Yoshihiro
AU  - Miyashita Y
FAU - Nakayama, Masahiro
AU  - Nakayama M
FAU - Suehara, Noriyuki
AU  - Suehara N
FAU - Funahashi, Tohru
AU  - Funahashi T
FAU - Shimomura, Iichiro
AU  - Shimomura I
FAU - Fujita, Tomio
AU  - Fujita T
LA  - eng
PT  - Journal Article
DEP - 20061003
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Adiponectin)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adiponectin/*blood
MH  - Birth Weight
MH  - Female
MH  - Fetal Blood/*chemistry
MH  - Fetal Development/physiology
MH  - Fetal Weight/*physiology
MH  - Fetus/anatomy & histology
MH  - Gestational Age
MH  - Humans
MH  - Insulin-Like Growth Factor I/analysis
MH  - Male
MH  - Mothers
MH  - Multivariate Analysis
MH  - Organ Size
MH  - Placenta/*anatomy & histology
MH  - Placentation
MH  - Pregnancy
MH  - Regression Analysis
EDAT- 2006/10/05 09:00
MHDA- 2007/01/26 09:00
CRDT- 2006/10/05 09:00
PHST- 2006/10/05 09:00 [pubmed]
PHST- 2007/01/26 09:00 [medline]
PHST- 2006/10/05 09:00 [entrez]
AID - jc.2005-2846 [pii]
AID - 10.1210/jc.2005-2846 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2006 Dec;91(12):5090-4. doi: 10.1210/jc.2005-2846. Epub 
      2006 Oct 3.