PMID- 17018901
OWN - NLM
STAT- MEDLINE
DCOM- 20100112
LR  - 20220716
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 23
IP  - 3
DP  - 2006
TI  - Unusual cyclin D1 positive marginal zone lymphoma of mediastinum.
PG  - 423-8
AB  - We report a case of 43-yr-old Caucasian female with an unusual, cyclin D1 
      positive marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT) 
      type of the mediastinum. To date, only about 30 cases of this entity have been 
      published. They occur mainly in Asian females with a history of coexisting 
      autoimmune disease. To our knowledge, this is the first case of mediastinal MZL 
      with cyclin D1 expression. In the span of 6 yr this patient's tumor recurred 
      three times, was surgically treated, and initially diagnosed as paraganglioma. 
      The diagnosis was based on histopathological examination only. Our final 
      diagnosis of MZL was made by combined evaluation of histopathology (HP), 
      immunohistochemistry (IH), flow cytometry (FCM), fluorescence in situ 
      hybridization (FISH), and molecular biology studies. We found a positive cyclin 
      D1 reaction by IH and cyclin D1 mRNA (CCND1) overexpression by reverse 
      transcription polymerase chain reaction (RT-PCR). Very high cyclin D1 to 
      beta-actin mRNA ratio in this case was comparable with the ratio, characteristic 
      for mantle cell lymphoma (MCL). However, there was no translocation t(11;14) 
      found by FISH and an immunophenotype by IH and FCM was consistent with MZL ruling 
      out MCL diagnosis. In addition, our case differs from other, previously reported 
      thymic MZL lymphoma cases by no autoimmune disease association, Caucasian origin, 
      and the absence of the plasmacytic differentiation on both HP/IH.
FAU - Rymkiewicz, Grzegorz
AU  - Rymkiewicz G
AD  - Department of Pathology, Centre of Oncology, Maria Sklodowska-Curie Memorial 
      Institute, Warsaw, Poland. grym@coi.waw.pl
FAU - Ptaszynski, Konrad
AU  - Ptaszynski K
FAU - Walewski, Jan
AU  - Walewski J
FAU - Blachnio, Katarzyna
AU  - Blachnio K
FAU - Swoboda, Pawel
AU  - Swoboda P
FAU - Gos, Monika
AU  - Gos M
FAU - Paszkiewicz-Kozik, Ewa
AU  - Paszkiewicz-Kozik E
FAU - Woroniecka, Renata
AU  - Woroniecka R
FAU - Pienkowska-Grela, Barbara
AU  - Pienkowska-Grela B
FAU - Czarnocka, Malgorzata
AU  - Czarnocka M
FAU - Janik, Przemyslaw
AU  - Janik P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adult
MH  - Cyclin D1/*biosynthesis
MH  - Female
MH  - Flow Cytometry/methods
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Lymphoma, B-Cell, Marginal Zone/*metabolism
MH  - Lymphoma, Mantle-Cell/genetics/pathology
MH  - Mediastinal Neoplasms/*metabolism
MH  - Models, Biological
MH  - Translocation, Genetic
EDAT- 2006/10/05 09:00
MHDA- 2010/01/13 06:00
CRDT- 2006/10/05 09:00
PHST- 2005/10/10 00:00 [received]
PHST- 1999/11/30 00:00 [revised]
PHST- 2005/12/28 00:00 [accepted]
PHST- 2006/10/05 09:00 [pubmed]
PHST- 2010/01/13 06:00 [medline]
PHST- 2006/10/05 09:00 [entrez]
AID - MO:23:3:423 [pii]
AID - 10.1385/MO:23:3:423 [doi]
PST - ppublish
SO  - Med Oncol. 2006;23(3):423-8. doi: 10.1385/MO:23:3:423.