PMID- 17020968
OWN - NLM
STAT- MEDLINE
DCOM- 20061109
LR  - 20061005
IS  - 1078-0432 (Print)
IS  - 1078-0432 (Linking)
VI  - 12
IP  - 19
DP  - 2006 Oct 1
TI  - Interphase fluorescence in situ hybridization analysis of chromosome 12p 
      abnormalities is useful for distinguishing epidermoid cysts of the testis from 
      pure mature teratoma.
PG  - 5668-72
AB  - PURPOSE: The distinction of epidermoid cyst of the testis from teratoma is of 
      critical importance because the former is benign and the latter is a malignant 
      tumor that may have associated metastasis of either teratomatous or 
      non-teratomatous germ cell tumor types. Chromosome 12p abnormalities are seen in 
      the vast majority of testicular germ cell tumors of adults and are present in all 
      histologic subtypes. In this study, we investigated the clinical utility of 
      interphase fluorescence in situ hybridization (FISH) analysis of chromosome 12p 
      abnormalities for distinguishing epidermoid cysts of the testis from pure mature 
      teratoma. EXPERIMENTAL DESIGN: Sixteen testicular epidermoid cysts and 17 
      testicular teratomas were investigated for isochromosome 12p [i(12p)] and 12p 
      overrepresentation using interphase FISH analysis. RESULTS: Neither i(12p) nor 
      12p overrepresentation were observed in 16 epidermoid cyst cases, whereas i(12p) 
      was detected in 76% of teratomas and 12p overrepresentation was identified in 29% 
      of teratomas. Overall, 88% of testicular teratomas had chromosome 12p 
      abnormalities. CONCLUSIONS: FISH identification of i(12p) and/or 12p 
      overrepresentation in routinely processed surgical specimens is a useful 
      ancillary diagnostic tool in distinguishing testicular epidermoid cysts from 
      teratoma.
FAU - Cheng, Liang
AU  - Cheng L
AD  - Departments of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, 350 West 11th Street, Indianapolis, IN 46202, USA. lcheng@iupui.edu
FAU - Zhang, Shaobo
AU  - Zhang S
FAU - MacLennan, Gregory T
AU  - MacLennan GT
FAU - Poulos, Christopher K
AU  - Poulos CK
FAU - Sung, Ming-Tse
AU  - Sung MT
FAU - Beck, Stephen D
AU  - Beck SD
FAU - Foster, Richard S
AU  - Foster RS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Cancer Res
JT  - Clinical cancer research : an official journal of the American Association for 
      Cancer Research
JID - 9502500
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - Epidermal Cyst/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Interphase
MH  - Karyotyping
MH  - Male
MH  - Teratoma/*genetics
MH  - Testicular Neoplasms/*genetics
MH  - Tumor Cells, Cultured
EDAT- 2006/10/06 09:00
MHDA- 2006/11/11 09:00
CRDT- 2006/10/06 09:00
PHST- 2006/10/06 09:00 [pubmed]
PHST- 2006/11/11 09:00 [medline]
PHST- 2006/10/06 09:00 [entrez]
AID - 12/19/5668 [pii]
AID - 10.1158/1078-0432.CCR-06-0976 [doi]
PST - ppublish
SO  - Clin Cancer Res. 2006 Oct 1;12(19):5668-72. doi: 10.1158/1078-0432.CCR-06-0976.