PMID- 17021407
OWN - NLM
STAT- MEDLINE
DCOM- 20061114
LR  - 20171116
IS  - 0022-3069 (Print)
IS  - 0022-3069 (Linking)
VI  - 65
IP  - 10
DP  - 2006 Oct
TI  - Latency of alpha-herpes viruses is accompanied by a chronic inflammation in human 
      trigeminal ganglia but not in dorsal root ganglia.
PG  - 1022-30
AB  - The immune response to latent herpesvirus infections was compared in human 
      trigeminal ganglia (TG) and dorsal root ganglia (DRG) of 15 dead individuals. On 
      the basis of our previous findings, we hypothesized that T-cells would be 
      attracted to sensory neurons latently infected with herpes simplex virus type 1 
      (HSV-1), but not to those harboring latent varicella zoster virus (VZV). We 
      showed that the TG contain a positive hybridization signal for HSV-1 
      latency-associated transcript (LAT), whereas the DRG from the same individuals 
      lack detectable LAT. In contrast, immunohistochemistry revealed that latent VZV 
      protein 62 stained positive in the vast majority of all tested TG and DRG. T-cell 
      infiltrates prominently surrounded individual neurons in the TG but not in the 
      DRG. TaqMan polymerase chain reaction also showed higher expression of CD8 and 
      RANTES transcripts in the TG versus DRG. Only the infiltrates in the TG, but not 
      in the DRG, produced RANTES at the protein level. Because it has been shown that 
      RANTES protein is produced only after T-cell receptor stimulation, we assume that 
      T-cell infiltration is associated with antigen recognition in the TG but not in 
      the DRG.
FAU - Hufner, Katharina
AU  - Hufner K
AD  - Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians University, 
      Munich, Germany.
FAU - Derfuss, Tobias
AU  - Derfuss T
FAU - Herberger, Simone
AU  - Herberger S
FAU - Sunami, Kishiko
AU  - Sunami K
FAU - Russell, Steven
AU  - Russell S
FAU - Sinicina, Inga
AU  - Sinicina I
FAU - Arbusow, Viktor
AU  - Arbusow V
FAU - Strupp, Michael
AU  - Strupp M
FAU - Brandt, Thomas
AU  - Brandt T
FAU - Theil, Diethilde
AU  - Theil D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
RN  - 0 (CD8 Antigens)
RN  - 0 (Chemokine CCL5)
RN  - 0 (MicroRNAs)
RN  - 0 (Viral Proteins)
RN  - 0 (latency associated transcript, herpes simplex virus-1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - CD8 Antigens/metabolism
MH  - Chemokine CCL5/metabolism
MH  - Child
MH  - Female
MH  - Ganglia, Spinal/immunology/pathology/*virology
MH  - Herpes Simplex/immunology/pathology
MH  - Herpes Zoster/immunology/pathology
MH  - Herpesvirus 1, Human/*physiology
MH  - Herpesvirus 3, Human/*physiology
MH  - Humans
MH  - Immunohistochemistry
MH  - Inflammation/pathology/*virology
MH  - Male
MH  - MicroRNAs
MH  - Middle Aged
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - T-Lymphocytes/immunology
MH  - Trigeminal Ganglion/immunology/pathology/*virology
MH  - Viral Proteins/metabolism
MH  - Virus Latency
EDAT- 2006/10/06 09:00
MHDA- 2006/11/15 09:00
CRDT- 2006/10/06 09:00
PHST- 2006/10/06 09:00 [pubmed]
PHST- 2006/11/15 09:00 [medline]
PHST- 2006/10/06 09:00 [entrez]
AID - 00005072-200610000-00010 [pii]
AID - 10.1097/01.jnen.0000235852.92963.bf [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 2006 Oct;65(10):1022-30. doi: 
      10.1097/01.jnen.0000235852.92963.bf.