PMID- 17022949
OWN - NLM
STAT- MEDLINE
DCOM- 20070123
LR  - 20071203
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1120
IP  - 1
DP  - 2006 Nov 20
TI  - Brain distribution of cytokine mRNA induced by systemic administration of 
      interleukin-1beta or tumor necrosis factor alpha.
PG  - 64-73
AB  - Brain cytokine mRNA levels are impacted by systemic cytokines. For example, 
      systemic interleukin-1beta (IL1beta) increases brain IL1beta mRNA; 
      subdiaphragmatic vagotomy blocks this effect. To localize which brain regions 
      respond to intraperitoneal cytokines, we measured mRNA levels in selected brain 
      regions for a variety of cytokines and growth factors, IL1beta, TNFalpha, 
      interleukin-6 (IL-6), interleukin-10 (IL10), nerve growth factor (NGF) and 
      brain-derived neurotrophic factor (BDNF). Relative to saline administration, 
      IL1beta increased IL1beta, TNFalpha and IL6 mRNAs in the nucleus tractus 
      solitarius (NTS), hypothalamus, hippocampus and somatosensory cortex (SSctx), but 
      did not induce any changes in IL10. TNFalpha also increased TNFalpha and IL1beta 
      mRNAs in the hypothalamus, hippocampus and SSctx. TNFalpha increased TNFalpha, 
      IL1beta and IL10 mRNAs in the NTS, but did not induce any changes in IL-6 mRNA. 
      In the amygdala, IL1beta enhanced IL6 mRNA and TNFalpha increased IL1beta mRNAs. 
      In the insular cortex, IL1beta enhanced IL6 mRNA and TNFalpha increased IL1beta 
      mRNA. TNFalpha administration increased NGF mRNA in the SSctx but decreased NGF 
      and BDNF mRNA levels in the insular cortex. Both IL1beta and TNFalpha decreased 
      BDNF mRNA in the amygdala. We also verified the IL1beta-induced increases in 
      TNFalpha mRNA within the NTS using in situ hybridization. These results support 
      the hypothesis that somnogenic doses of IL1beta and TNFalpha enhance their own 
      mRNA levels as well as affect mRNA levels for other sleep-promoting substances.
FAU - Churchill, Lynn
AU  - Churchill L
AD  - Department of Veterinary and Comparative Anatomy, Program in Neuroscience, 
      Washington State University, Pullman, WA 99164-6520, USA.
FAU - Taishi, Ping
AU  - Taishi P
FAU - Wang, Mingfei
AU  - Wang M
FAU - Brandt, Judith
AU  - Brandt J
FAU - Cearley, Cassia
AU  - Cearley C
FAU - Rehman, Abdur
AU  - Rehman A
FAU - Krueger, James M
AU  - Krueger JM
LA  - eng
GR  - NS25378/NS/NINDS NIH HHS/United States
GR  - NS31453/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20061003
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1beta)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Brain/anatomy & histology/*drug effects/metabolism
MH  - Cytokines/genetics/*metabolism
MH  - Gene Expression/*drug effects
MH  - In Situ Hybridization/methods
MH  - Interleukin-1beta/*administration & dosage
MH  - Male
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/*administration & dosage
EDAT- 2006/10/07 09:00
MHDA- 2007/01/24 09:00
CRDT- 2006/10/07 09:00
PHST- 2006/01/25 00:00 [received]
PHST- 2006/08/11 00:00 [revised]
PHST- 2006/08/22 00:00 [accepted]
PHST- 2006/10/07 09:00 [pubmed]
PHST- 2007/01/24 09:00 [medline]
PHST- 2006/10/07 09:00 [entrez]
AID - S0006-8993(06)02595-9 [pii]
AID - 10.1016/j.brainres.2006.08.083 [doi]
PST - ppublish
SO  - Brain Res. 2006 Nov 20;1120(1):64-73. doi: 10.1016/j.brainres.2006.08.083. Epub 
      2006 Oct 3.