PMID- 17023054
OWN - NLM
STAT- MEDLINE
DCOM- 20070122
LR  - 20151119
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 180
IP  - 1-2
DP  - 2006 Nov
TI  - Frequency analysis of HLA-B7-restricted Epstein-Barr virus-specific cytotoxic T 
      lymphocytes in patients with multiple sclerosis and healthy controls.
PG  - 185-92
AB  - The Epstein-Barr virus (EBV) has been implicated in the pathogenesis of multiple 
      sclerosis (MS), however, the mechanisms by which EBV may be involved in MS are 
      unknown. We here have investigated the frequency of EBV-specific cytotoxic T 
      lymphocytes (CTL) in human leukocyte antigen (HLA)-B7(+) patients with MS and 
      healthy controls using enzyme-linked immunospot assays and seven previously 
      characterized HLA-B7-restricted immunogenic EBV peptides. Overall, there were no 
      significant differences in the frequency of EBV-specific CTL between both groups. 
      These data do not support the hypothesis that EBV could play a role in MS by 
      inducing quantitatively altered EBV-specific CTL responses. Other pathogenic 
      mechanisms for EBV in MS remain to be elucidated.
FAU - Gronen, Felix
AU  - Gronen F
AD  - Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of 
      Neurology, Julius-Maximilians Universitat Wurzburg, 97080 Wurzburg, Germany.
FAU - Ruprecht, Klemens
AU  - Ruprecht K
FAU - Weissbrich, Benedikt
AU  - Weissbrich B
FAU - Klinker, Erdwine
AU  - Klinker E
FAU - Kroner, Antje
AU  - Kroner A
FAU - Hofstetter, Harald H
AU  - Hofstetter HH
FAU - Rieckmann, Peter
AU  - Rieckmann P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061004
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 0 (Biomarkers)
RN  - 0 (HLA-B7 Antigen)
RN  - 0 (Tetanus Toxoid)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/genetics/immunology
MH  - Antigens, Viral/genetics/immunology
MH  - Biomarkers/blood
MH  - Cell Count
MH  - Cell Proliferation
MH  - Female
MH  - Genotype
MH  - HLA-B7 Antigen/genetics/*immunology
MH  - Herpesvirus 4, Human/genetics/*immunology
MH  - Humans
MH  - Immunity, Cellular/drug effects/immunology
MH  - Lymphocyte Activation/immunology
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/genetics/*immunology/*virology
MH  - Reference Values
MH  - T-Lymphocytes, Cytotoxic/*immunology/*virology
MH  - Tetanus Toxoid/immunology/pharmacology
MH  - Viral Load
EDAT- 2006/10/07 09:00
MHDA- 2007/01/24 09:00
CRDT- 2006/10/07 09:00
PHST- 2006/06/13 00:00 [received]
PHST- 2006/08/22 00:00 [revised]
PHST- 2006/08/25 00:00 [accepted]
PHST- 2006/10/07 09:00 [pubmed]
PHST- 2007/01/24 09:00 [medline]
PHST- 2006/10/07 09:00 [entrez]
AID - S0165-5728(06)00333-X [pii]
AID - 10.1016/j.jneuroim.2006.08.008 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2006 Nov;180(1-2):185-92. doi: 10.1016/j.jneuroim.2006.08.008. 
      Epub 2006 Oct 4.