PMID- 17023106
OWN - NLM
STAT- MEDLINE
DCOM- 20070315
LR  - 20140325
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 31
IP  - 1
DP  - 2007 Jan 30
TI  - Rewarding effects of 3,4-methylenedioxymethamphetamine ("Ecstasy") in dominant 
      and subordinate OF-1 mice in the place preference conditioning paradigm.
PG  - 191-9
AB  - We tested the ability of 3,4-methylenedioxymethamphetamine (MDMA) to induce 
      conditioned place preference (CPP) in dominant and subordinate OF-1 mice 
      subjected to cohabitation and repeated sessions of agonistic confrontation, as 
      well as in non-confronted mice. We selected doses of MDMA (2, 6, 10 mg/kg) 
      previously reported to induce CPP in mice and we measured expression of c-Fos 
      evoked by the treatments in non-confronted mice. MDMA induced c-Fos protein in 
      several corticolimbic regions involved in drug-induced reward. Mice were exposed 
      to brief sessions of agonistic confrontation on 5 consecutive days. 
      Determinations of circulating hormones and drug conditioning tests were carried 
      out on completion of the encounters. The results of hormone assays indicated that 
      dominant mice had higher serum concentrations of testosterone, but lower levels 
      of corticosterone, than submissive mice. Post-conditioning tests after drug 
      conditioning (4 injections of MDMA or saline on alternate days) showed that MDMA 
      significantly produced CPP at doses of 2 and 6 mg/kg, but not at 10 mg/kg, an 
      inverted U-shaped pattern of conditioning that was invariable in non-confronted, 
      dominant and subordinate mice. These results demonstrate that the endocrine and 
      behavioural correlates linked to social status and social stress in mice are not 
      paralleled by significant changes in the rewarding efficacy of MDMA in the CPP 
      paradigm under the specific conditions tested.
FAU - Rodriguez-Alarcon, G
AU  - Rodriguez-Alarcon G
AD  - Department of Psychobiology, University of Valencia, Valencia, Spain.
FAU - Canales, J J
AU  - Canales JJ
FAU - Salvador, A
AU  - Salvador A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061004
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Serotonin Agents)
RN  - 3XMK78S47O (Testosterone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Agonistic Behavior/drug effects
MH  - Animals
MH  - Conditioning, Operant/*drug effects
MH  - Corticosterone/blood
MH  - *Dominance-Subordination
MH  - Gene Expression/drug effects
MH  - Genes, fos/drug effects
MH  - Immunohistochemistry
MH  - Male
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - *Reward
MH  - Serotonin Agents/*pharmacology
MH  - Social Environment
MH  - Stress, Psychological/psychology
MH  - Testosterone/blood
EDAT- 2006/10/07 09:00
MHDA- 2007/03/16 09:00
CRDT- 2006/10/07 09:00
PHST- 2006/05/27 00:00 [received]
PHST- 2006/08/24 00:00 [revised]
PHST- 2006/08/25 00:00 [accepted]
PHST- 2006/10/07 09:00 [pubmed]
PHST- 2007/03/16 09:00 [medline]
PHST- 2006/10/07 09:00 [entrez]
AID - S0278-5846(06)00338-1 [pii]
AID - 10.1016/j.pnpbp.2006.08.018 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):191-9. doi: 
      10.1016/j.pnpbp.2006.08.018. Epub 2006 Oct 4.