PMID- 17023662
OWN - NLM
STAT- MEDLINE
DCOM- 20061018
LR  - 20230921
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 314
IP  - 5796
DP  - 2006 Oct 6
TI  - Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior.
PG  - 140-3
AB  - A common single-nucleotide polymorphism in the brain-derived neurotrophic factor 
      (BDNF) gene, a methionine (Met) substitution for valine (Val) at codon 66 
      (Val66Met), is associated with alterations in brain anatomy and memory, but its 
      relevance to clinical disorders is unclear. We generated a variant BDNF mouse 
      (BDNF(Met/Met)) that reproduces the phenotypic hallmarks in humans with the 
      variant allele. BDNF(Met) was expressed in brain at normal levels, but its 
      secretion from neurons was defective. When placed in stressful settings, 
      BDNF(Met/Met) mice exhibited increased anxiety-related behaviors that were not 
      normalized by the antidepressant, fluoxetine. A variant BDNF may thus play a key 
      role in genetic predispositions to anxiety and depressive disorders.
FAU - Chen, Zhe-Yu
AU  - Chen ZY
AD  - Department of Psychiatry, Weill Medical College of Cornell University, New York, 
      NY 10021, USA. zheyuchen@sdu.edu.cn
FAU - Jing, Deqiang
AU  - Jing D
FAU - Bath, Kevin G
AU  - Bath KG
FAU - Ieraci, Alessandro
AU  - Ieraci A
FAU - Khan, Tanvir
AU  - Khan T
FAU - Siao, Chia-Jen
AU  - Siao CJ
FAU - Herrera, Daniel G
AU  - Herrera DG
FAU - Toth, Miklos
AU  - Toth M
FAU - Yang, Chingwen
AU  - Yang C
FAU - McEwen, Bruce S
AU  - McEwen BS
FAU - Hempstead, Barbara L
AU  - Hempstead BL
FAU - Lee, Francis S
AU  - Lee FS
LA  - eng
GR  - NS30687/NS/NINDS NIH HHS/United States
GR  - R01 NS052819/NS/NINDS NIH HHS/United States
GR  - MH068850/MH/NIMH NIH HHS/United States
GR  - MH060478/MH/NIMH NIH HHS/United States
GR  - NS052819/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 01K63SUP8D (Fluoxetine)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Anxiety/drug therapy/*genetics
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/*genetics/*physiology
MH  - Conditioning, Psychological
MH  - Dendrites/ultrastructure
MH  - Dentate Gyrus/cytology
MH  - Fear
MH  - Fluoxetine/administration & dosage/pharmacology
MH  - Hippocampus/anatomy & histology/metabolism
MH  - Memory
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Motor Activity
MH  - Neurons/cytology/metabolism
MH  - Organ Size
MH  - *Polymorphism, Single Nucleotide
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Selective Serotonin Reuptake Inhibitors/administration & dosage/pharmacology
PMC - PMC1880880
MID - NIHMS20428
EDAT- 2006/10/07 09:00
MHDA- 2006/10/19 09:00
PMCR- 2007/05/30
CRDT- 2006/10/07 09:00
PHST- 2006/10/07 09:00 [pubmed]
PHST- 2006/10/19 09:00 [medline]
PHST- 2006/10/07 09:00 [entrez]
PHST- 2007/05/30 00:00 [pmc-release]
AID - 314/5796/140 [pii]
AID - 10.1126/science.1129663 [doi]
PST - ppublish
SO  - Science. 2006 Oct 6;314(5796):140-3. doi: 10.1126/science.1129663.