PMID- 17024545
OWN - NLM
STAT- MEDLINE
DCOM- 20070501
LR  - 20181113
IS  - 0179-051X (Print)
IS  - 0179-051X (Linking)
VI  - 22
IP  - 1
DP  - 2007 Jan
TI  - Eosinophilic esophagitis in infants and toddlers.
PG  - 44-8
AB  - Feeding refusal is often described in conjunction with the diagnosis of 
      eosinophilic esophagitis (EE) in pediatric patients; however, there are little 
      data regarding the specific clinical manifestations and effective management of 
      this condition in very young children. The aim of this study was to evaluate the 
      presentation of EE in infants and toddlers referred to the Interdisciplinary 
      Feeding Team Clinic of a tertiary referral center and to document responses to 
      treatment. Database matching was performed (from January 2000 to June 2003) to 
      identify infants and toddlers diagnosed with EE who had been referred to the 
      Interdisciplinary Feeding Team Clinic. Endoscopic features required for a 
      diagnosis of EE included esophageal mucosal furrowing, erythema, exudates, or 
      decreased vascular markings. Histologic features of EE were more than 24 
      eosinophils per high-power field (HPF), thickening of basal cell layer, and 
      papillary (rete peg) lengthening or elongation. All study patients were treated 
      with a combination of proton pump inhibitors (PPI) and fluticasone (swallowed). 
      In addition, elemental diet was instituted in those documented to have a food 
      allergy. Treatment success was defined by an improved oral intake, adequate 
      weight gain, and improved endoscopic and histologic findings at 3-6-month 
      followup. A total of 15 subjects [mean age = 19.9 months (SD = 9.7 months)] who 
      fulfilled the entry criteria during the study period were identified. All 15 
      children had documented endoscopic improvement and 14/15 children had histologic 
      resolution of EE after therapy. In 13 of the 15 children, this translated to 
      clinical improvement as well.
FAU - Pentiuk, Scott P
AU  - Pentiuk SP
AD  - Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 
      Cincinnati, Ohio 45229, USA.
FAU - Miller, Claire Kane
AU  - Miller CK
FAU - Kaul, Ajay
AU  - Kaul A
LA  - eng
PT  - Journal Article
DEP - 20061006
PL  - United States
TA  - Dysphagia
JT  - Dysphagia
JID - 8610856
SB  - IM
MH  - Child, Preschool
MH  - *Deglutition
MH  - Deglutition Disorders/*diagnosis/physiopathology
MH  - Eosinophilia/*diagnosis/drug therapy/physiopathology
MH  - Esophagitis/*diagnosis/drug therapy/physiopathology
MH  - *Feeding Behavior
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Retrospective Studies
EDAT- 2006/10/07 09:00
MHDA- 2007/05/02 09:00
CRDT- 2006/10/07 09:00
PHST- 2005/07/28 00:00 [received]
PHST- 2006/07/12 00:00 [accepted]
PHST- 2006/10/07 09:00 [pubmed]
PHST- 2007/05/02 09:00 [medline]
PHST- 2006/10/07 09:00 [entrez]
AID - 10.1007/s00455-006-9040-9 [doi]
PST - ppublish
SO  - Dysphagia. 2007 Jan;22(1):44-8. doi: 10.1007/s00455-006-9040-9. Epub 2006 Oct 6.