PMID- 1702664
OWN - NLM
STAT- MEDLINE
DCOM- 19910220
LR  - 20191021
IS  - 0163-4984 (Print)
IS  - 0163-4984 (Linking)
VI  - 24
IP  - 2
DP  - 1990 Feb
TI  - High dose antioxidant supplementation to MS patients. Effects on glutathione 
      peroxidase, clinical safety, and absorption of selenium.
PG  - 109-17
AB  - High-dose antioxidant supplementation has recently been recommended for multiple 
      sclerosis (MS) patients. This study tests the clinical safety, the glutathione 
      peroxidase (GSH-px) activity, and the absorption of selenium during such 
      supplementation. Eighteen MS patients were given 6 tablets especially made for 
      this study, equivalent to 6 mg sodium selenite, 2 g vitamin C, and 480 mg vitamin 
      E a day for five wk. GSH-px, which was lower than in non-MS controls before the 
      start of treatment, increased fivefold during 5 wk of treatment. Side effects 
      were scarce. Ten MS patients were subjected to a 24-h selenium absorption study 
      after ingestion of 2 active tablets, equivalent to 2 mg sodium selenite. 
      Selenium, which was low initially, increased 24% during the first 3 h and then 
      stabilized. It is concluded that the tested antioxidant treatment seems to be 
      safe and that MS patients have low GSH-px, which may be increased by the tested 
      antioxidant treatment.
FAU - Mai, J
AU  - Mai J
AD  - Department of Neurology, Arhus Kommunehospital, Denmark.
FAU - Sorensen, P S
AU  - Sorensen PS
FAU - Hansen, J C
AU  - Hansen JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0 (Antioxidants)
RN  - 0 (Tablets)
RN  - 1406-18-4 (Vitamin E)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - H6241UJ22B (Selenium)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Absorption
MH  - Adolescent
MH  - Adult
MH  - Antioxidants/administration & dosage/*pharmacokinetics
MH  - Ascorbic Acid/blood/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Evaluation
MH  - Female
MH  - Glutathione Peroxidase/*blood
MH  - Humans
MH  - Lymphocytes/drug effects/enzymology
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/drug therapy/*metabolism
MH  - Selenium/administration & dosage/*pharmacokinetics
MH  - Tablets
MH  - Vitamin E/blood/pharmacology
EDAT- 1990/02/01 00:00
MHDA- 1990/02/01 00:01
CRDT- 1990/02/01 00:00
PHST- 1990/02/01 00:00 [pubmed]
PHST- 1990/02/01 00:01 [medline]
PHST- 1990/02/01 00:00 [entrez]
AID - 10.1007/BF02917200 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 1990 Feb;24(2):109-17. doi: 10.1007/BF02917200.