PMID- 17027562
OWN - NLM
STAT- MEDLINE
DCOM- 20061124
LR  - 20131121
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 98
IP  - 8
DP  - 2006 Oct 15
TI  - Genotype-phenotype association of matrix metalloproteinase-3 polymorphism and its 
      synergistic effect with smoking on the occurrence of acute coronary syndrome.
PG  - 1012-7
AB  - Matrix metalloproteinase-3 (MMP-3) degrades the extracellular matrix and may 
      contribute to the weakening of the plaque cap. To determine whether 
      genotype-phenotype associations differed in different categories of acute 
      coronary syndrome, we enrolled 650 consecutive Taiwanese patients diagnosed with 
      acute coronary syndrome. Genotypic analysis was done on DNA using polymerase 
      chain reaction and direct sequencing on the 5 adenines (5A)/6 adenines (6A; 
      -1,171 bp) polymorphism in the MMP-3 gene promoter region. The frequency of the 
      5A polymorphism was higher in patients with acute coronary syndrome, especially 
      in those with ST-elevation myocardial infarction (p <0.01). The number of 5A 
      allele polymorphisms was strongly associated with more complex coronary 
      angiography (diffuse score for 5A/5A vs 5A/6A vs 6A/6A, 6.6 +/- 1.2 vs 5.3 +/- 
      1.3 vs 4.6 +/- 1.1, all p values <0.05 in subgroup analysis) and higher plasma 
      MMP-3 activity in this acute coronary syndrome cohort (MMP-3 level for 6A/6A vs 
      5A/6A vs 5A/5A, 21.0 +/- 2.2 vs 23.3 +/- 2.1 vs 27.9 +/- 2.2 ng/ml, all p values 
      <0.05 in subgroup analysis). Multiple logistic regression analysis showed that 
      this polymorphism, in addition to hypertension, diabetes, and a history of 
      smoking, was an independent risk factor (odds ratio 2.2, 95% confidence interval 
      1.1 to 4.3, p = 0.02) for the occurrence of acute coronary syndrome. Further, 
      carriers of this polymorphism who smoked had a significantly increased (20-fold) 
      risk of acute coronary syndrome compared with nonsmoking noncarriers. In 
      conclusion, the MMP-3 5A/6A polymorphism is significantly associated with the 
      occurrence of acute coronary syndrome, MMP-3 activity, and severity of coronary 
      atherosclerosis. There is a synergistic effect between smoking and this genetic 
      risk factor for acute coronary syndrome.
FAU - Liu, Ping-Yen
AU  - Liu PY
AD  - Division of Cardiology, Department of Internal Medicine, College of Medicine, 
      National Cheng Kung University, Tainan, Taiwan.
FAU - Li, Yi-Heng
AU  - Li YH
FAU - Chan, Shih-Hung
AU  - Chan SH
FAU - Lin, Li-Jen
AU  - Lin LJ
FAU - Wu, Hua-Lin
AU  - Wu HL
FAU - Shi, Guey-Yueh
AU  - Shi GY
FAU - Chen, Jyh-Hong
AU  - Chen JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060822
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Acute Disease
MH  - Case-Control Studies
MH  - Cholesterol/blood
MH  - Cohort Studies
MH  - Coronary Disease/*etiology/*genetics
MH  - Diabetes Complications
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Hypertension/complications
MH  - Male
MH  - Matrix Metalloproteinase 3/blood/*genetics
MH  - Middle Aged
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Smoking/*adverse effects
EDAT- 2006/10/10 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/10/10 09:00
PHST- 2006/02/15 00:00 [received]
PHST- 2006/05/01 00:00 [revised]
PHST- 2006/05/01 00:00 [accepted]
PHST- 2006/10/10 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/10/10 09:00 [entrez]
AID - S0002-9149(06)01273-2 [pii]
AID - 10.1016/j.amjcard.2006.05.017 [doi]
PST - ppublish
SO  - Am J Cardiol. 2006 Oct 15;98(8):1012-7. doi: 10.1016/j.amjcard.2006.05.017. Epub 
      2006 Aug 22.