PMID- 17030435
OWN - NLM
STAT- MEDLINE
DCOM- 20070104
LR  - 20061106
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 409
IP  - 3
DP  - 2006 Dec 6
TI  - Participation of peripheral group I and II metabotropic glutamate receptors in 
      the development or maintenance of IL-1beta-induced mechanical allodynia in the 
      orofacial area of conscious rats.
PG  - 173-8
AB  - The present study investigated the role of peripheral groups I and II 
      metabotropic glutamate receptors (mGluRs) in interleukin (IL)-1beta-induced 
      mechanical allodynia in the orofacial area of rats. Subcutaneous injection of 10 
      pg of IL-1beta decreased air-puff thresholds ipsilateral or contralateral to the 
      injection site. The decrease in air-puff thresholds appeared 10 min after the 
      injection of IL-1beta and IL-1beta-induced mechanical allodynia persisted for 
      over 3 h. Pre-treatment with 7-(hydroxyimino) cyclopropa[b] 
      chromen-1a-carboxylate ethyl ester (CPCCOEt) or 
      2-methyl-6-(phenylethynyl)-pyridine hydrochloride (MPEP), a mGluR1 or mGluR5 
      antagonist, blocked IL-1beta-induced mechanical allodynia and mirror-image 
      mechanical allodynia produced by a subcutaneous injection of 10 pg of IL-1beta. 
      However, post-treatment with CPCCOEt or MPEP did not affect changes in behavioral 
      responses, which were produced by the IL-1beta injection. Pre-treatment, as well 
      as post-treatment with (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (APDC), a 
      group II mGluR agonist, blocked either IL-1beta-induced mechanical allodynia or 
      mirror-image mechanical allodynia. The anti-allodynic effects of APDC were 
      abolished by pre-treatment with 
      (2S)-2-amino-2[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid 
      (LY341495), a group II mGluR antagonist. These results indicate that peripheral 
      group II mGluRs are involved in the development and maintenance of 
      IL-1beta-induced mechanical allodynia, while peripheral group I mGluRs are 
      involved in the development of IL-1beta-induced mechanical allodynia. Based on 
      our observations, the peripheral application of group II mGluR agonists may be of 
      therapeutic value in treating inflammatory pain.
FAU - Jung, Chang Y
AU  - Jung CY
AD  - Department of Oral Physiology and BrainKorea 21, School of Dentistry, Kyungpook 
      University, Daegu, South Korea.
FAU - Lee, Sang Y
AU  - Lee SY
FAU - Choi, Hyo S
AU  - Choi HS
FAU - Lim, Eun J
AU  - Lim EJ
FAU - Lee, Min K
AU  - Lee MK
FAU - Yang, Gwi Y
AU  - Yang GY
FAU - Han, Seung R
AU  - Han SR
FAU - Youn, Dong H
AU  - Youn DH
FAU - Ahn, Dong K
AU  - Ahn DK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061006
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Interleukin-1beta)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0 (metabotropic glutamate receptor 2)
RN  - 0 (metabotropic glutamate receptor type 1)
SB  - IM
MH  - Animals
MH  - Consciousness
MH  - Facial Pain/chemically induced/*metabolism
MH  - Hyperesthesia/chemically induced/*metabolism
MH  - *Interleukin-1beta
MH  - Rats
MH  - Receptors, Metabotropic Glutamate/*metabolism
MH  - Touch/*drug effects
EDAT- 2006/10/13 09:00
MHDA- 2007/01/05 09:00
CRDT- 2006/10/13 09:00
PHST- 2006/07/18 00:00 [received]
PHST- 2006/09/18 00:00 [revised]
PHST- 2006/09/18 00:00 [accepted]
PHST- 2006/10/13 09:00 [pubmed]
PHST- 2007/01/05 09:00 [medline]
PHST- 2006/10/13 09:00 [entrez]
AID - S0304-3940(06)01004-4 [pii]
AID - 10.1016/j.neulet.2006.09.043 [doi]
PST - ppublish
SO  - Neurosci Lett. 2006 Dec 6;409(3):173-8. doi: 10.1016/j.neulet.2006.09.043. Epub 
      2006 Oct 6.